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    • DISCOVER ONCOLOGY Journal

    Papers
    A Temting Target? - Clinical and Experimental Evidence for Epithelial-Mesenchymal Transition in the Progression of Cutaneous Squamous Cell Carcinoma (A Scoping Systematic Review)
    Genenger Benjamin,Perry Jay R.,Ashford Bruce,Ranson Marie
    Discover oncology（2022）
    Cutaneous squamous cell carcinoma (cSCC) is a disease with globally rising incidence and poor prognosis for patients with advanced or metastatic disease. Epithelial-mesenchymal transition (EMT) is a driver of metastasis in many carcinomas, and cSCC is no exception. We aimed to pr...
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    Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for CHDs in Human Lung Cancer
    Lv Yang,Lin Wenchu
    Discover Oncology（2022）
    Background The chromodomain helicase DNA-binding (CHD) family, a group of genes that regulate nucleosome spacing and access to transcription factors, contributes to tumorigenesis in various cancers. However, the roles of CHD family members in lung cancer remain poorly understood....
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    O-GlcNAcylation links oncogenic signals and cancer epigenetics
    Lidong Sun,Suli Lv,Tanjing Song
    DISCOVER ONCOLOGY（2021）
    Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer therapy. Understanding how conventional oncogenic factors cause epigenetic abnormality is of great basic and translational value. O-Gl...
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    Combination Bromo- and Extraterminal Domain and Poly (Adp-Ribose) Polymerase Inhibition Synergistically Enhances DNA Damage and Inhibits Neuroblastoma Tumorigenesis
    Jillian C. Jacobson,Jingbo Qiao,Rachael A. Clark,Dai H. Chung
    Journal of the American College of Surgeons（2022）
    Purpose JQ1 is a bromo- and extraterminal (BET) domain inhibitor that downregulates MYC expression and impairs the DNA damage response. Poly (ADP-ribose) polymerase (PARP) inhibitors prevent DNA damage sensing and repair. We hypothesized that JQ1 would promote a DNA repair-defici...
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    LncRNA POU3F3 Promotes Melanoma Cell Proliferation by Downregulating Lncrna MEG3
    Li Chaofei
    Discover Oncology（2021）
    Background LncRNA POU3F3 (POU3F3) is overexpressed and plays oncogenic roles in esophageal squamous-cell carcinomas. LncRNA MEG3 (MEG3) has been characterized as a tumor suppressive lncRNA in different types of cancer. Our preliminary deep sequencing analysis revealed the inverse...
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    Subcellular Localization of HMGB1 in Human Cholangiocarcinoma: Correlation with Tumor Stage
    Suwannakul Nattawan,Midorikawa Kaoru,Du Chunping,Qi Ya-Peng,Zhang Jie,Xiang Bang-De,Murata Mariko,Ma Ning
    Discover Oncology（2021）
    Cholangiocarcinoma (CCA) is a malignant disease with a poor prognosis, and several studies have been conducted using different molecular markers as a tool for CCA diagnosis, including Clonorchis sinensis (CS)-CCA. We initially identified the expression profiles of the three marke...
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    PD-L1 Expression in EBV Associated Gastric Cancer: a Systematic Review and Meta-Analysis
    Lima Áurea,Sousa Hugo,Medeiros Rui,Nobre Amanda,Machado Manuela
    Discover Oncology（2022）
    Objectives The aim of this systematic review and meta-analysis is to the summarize the evidence on programmed cell death protein ligand 1 (PD-L1) in Epstein-Barr virus associated gastric cancer (EBVaGC) and to estimate the expression rate of PD-L1 among this subtype of Gastric Ca...
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    Clinicopathological Factors Associated with Recurrence in Patients Undergoing Resection of Pancreatic Solid Pseudopapillary Neoplasm
    Paredes Oscar,Paredes Kori,Kawaguchi Yoshikuni,Luque-Vasquez Carlos,Chavez Iván,Celis Juan,Payet Eduardo,Ruiz Eloy,Berrospi Francisco
    Discover Oncology（2021）
    Abstract Purpose Solid pseudopapillary neoplasm (SPN) is an uncommon pathology with a low-grade malignancy. Surgery is the milestone treatment. Nevertheless, despite appropriate management, some patients present recurrence. Risk factors associated with recurrence are unclear. The...
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    The Role of Insulin and Incretin-Based Drugs in Biliary Tract Cancer: Epidemiological and Experimental Evidence
    Sun Hua,Qi Xiaohui
    Discover Oncology（2022）
    Insulin and incretin-based drugs are important antidiabetic agents with complex effects on cell growth and metabolism. Emerging evidence shows that insulin and incretin-based drugs are associated with altered risk of biliary tract cancer (BTC). Observational study reveals that in...
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    The Relationship Between CD204 M2-polarized Tumour-Associated Macrophages (tams), Tumour-Infiltrating Lymphocytes (tils), and Microglial Activation in Glioblastoma Microenvironment: a Novel Immune Checkpoint Receptor Target
    Kurdi Maher,Alghamdi Badrah,Butt Nadeem Shafique,Baeesa Saleh
    Discover Oncology（2021）
    Abstract Background Tumour associated macrophages (TAMs) and tumour infiltrating lymphocytes (TILs) are considered dominant cells in glioblastoma microenvironment. Aim The purpose of this study was to assess the expression of CD204+ M2-polarized TAMs in glioblastomas and their re...
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    Integrated in Silico Analysis of LRP2 Mutations to Immunotherapy Efficacy in Pan-Cancer Cohort
    Li Chunbo,Ding Yan,Zhang Xuyin,Hua Keqin
    Discover Oncology（2022）
    PURPOSE:Immunotherapy has emerged as a novel therapy, while many patients are refractory. Although, several biomarkers have been identified as predictive biomarkers for immunotherapy, such as tumor specific genes, PD-1/PD-L1, tumor mutation burn (TMB), and microsatellite instabil...
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    Exploration of Biomarkers for the Diagnosis, Treatment and Prognosis of Cervical Cancer: a Review
    Arip Masita,Tan Lee Fang,Jayaraj Rama,Abdullah Maha,Rajagopal Mogana,Selvaraja Malarvili
    Discover Oncology（2022）
    As the fourth most diagnosed cancer, cervical cancer (CC) is one of the major causes of cancer-related mortality affecting females globally, particularly when diagnosed at advanced stage. Discoveries of CC biomarkers pave the road to precision medicine for better patient outcomes...
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    Vitality, Viability, Long-Term Clonogenic Survival, Cytotoxicity, Cytostasis and Lethality: What Do They Mean when Testing New Investigational Oncology Drugs
    Benjamin N. Forgie,Rewati Prakash,Alicia A. Goyeneche,Carlos M. Telleria
    Discover Oncology（2024）
    AbstractIn the field of experimental therapeutics for oncology purposes researchers are continuously evaluating the toxicity of novel treatment approaches against cancer cells. Within this topic of research, it is highly critical to define parameters of toxicity that denote when ...
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    The Prognostic Significance of Primary Tumor Size in Squamous Cell Carcinoma of the Penis
    Li Kai,Wu Guang,Fan Caibin,Yuan Hexing
    Discover Oncology（2021）
    Abstract Background To evaluate the association of primary tumor size with clinicopathologic characteristics and survival of patients with squamous cell carcinoma of the penis (SCCP). Methods This study analyzed the data of 1001 patients with SCCP, obtained from the National Canc...
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    Antibiotics in Early Life and Childhood Pre-B-all. Reasons to Analyze a Possible New Piece in the Puzzle
    Cardesa-Salzmann T. M.,Simon A.,Graf N.
    Discover Oncology（2022）
    Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with precursor B-cell ALL (pB-ALL) accounting for ~ 85% of the cases. Childhood pB-ALL development is influenced by genetic susceptibility and host immune responses. The role of the intestinal microbiome in le...
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    Extremely High Conservation in the Untranslated Region As Well As the Coding Region of CNP Mrnas Throughout Elasmobranch Species
    Susumu Hyodo,Akatsuki Kawakoshi,Ray C. Bartolo,Yoshio Takei,Tes Toop,John A. Donald
    General and Comparative Endocrinology（2006）
    C-type natriuretic peptide (CNP) is a crucial osmoregulatory hormone in elasmobranchs, participating in salt secretion and drinking. In contrast to teleosts and tetrapods in which the NP family is composed of a group of structurally related peptides, we have shown that CNP is the...
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    Mapping Human Papillomavirus, Epstein–Barr Virus, Cytomegalovirus, Adenovirus, and P16 in Laryngeal Cancer
    Schindele Alexandra,Holm Anna,Nylander Karin,Allard Annika,Olofsson Katarina
    Discover Oncology（2022）
    Abstract Purpose Apart from tobacco and alcohol, viral infections are proposed as risk factors for laryngeal cancer. The occurrence of oncogenic viruses including human papilloma virus (HPV) and Epstein–Barr virus (EBV), in laryngeal squamous cell carcinoma (LSCC) varies in the w...
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    Complete Remission of Recurrent Multiple Insulin-Producing Neuroendocrine Tumors of the Pancreas with Somatostatin Analogs: A Case Report and Literature Review
    Tartaglia Andreas, Busonero Giulia, Gagliardi Lorenza, Boddi Valentina,Pieri Federica,Nizzoli Maurizio
    Discover Oncology（2022）
    Hyperinsulinemic hypoglycemia is most commonly caused by a single, sporadic insulinoma. Multicentric insulinoma disease (insulinomatosis) as well as metachronous neuroendocrine tumors of the pancreas, known also as neuroendocrine adenomatosis, represent a very rare condition, if ...
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    DCE-MRI Radiomics Nomogram Can Predict Response to Neoadjuvant Chemotherapy in Esophageal Cancer
    Qu Jinrong,Ma Ling,Lu Yanan,Wang Zhaoqi,Guo Jia,Zhang Hongkai,Yan Xu,Liu Hui,Kamel Ihab R.,Li Hailiang
    Discover Oncology（2022）
    Abstract Objectives To assess volumetric DCE-MRI radiomics nomogram in predicting response to neoadjuvant chemotherapy (nCT) in EC patients. Methods This retrospective analysis of a prospective study enrolled EC patients with stage cT1N + M0 or cT2-4aN0-3M0 who received DCE-MRI w...
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    The Gold Complex Auranofin: New Perspectives for Cancer Therapy
    Abdalbari Farah H., Cancer Research Program, Research Institute, McGill University Health Centre
    Discover Oncology（2021）
    Advanced stages of cancer are highly associated with short overall survival in patients due to the lack of long-term treatment options following the standard form of care. New options for cancer therapy are needed to improve the survival of cancer patients without disease recurre...
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