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    • Non-coding RNA Research Journal

    Papers
    Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis
    Jameel M. Abduljalil
    Non-coding RNA Research（2018）
    Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or key metabolites, changes in surrounding pH, and temperature shifts are the most i...
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    Long Non-Coding RNAs: Functional Regulatory Players in Breast Cancer
    Rana Ahmed Youness,Mohamed Zakaria Gad
    Non-coding RNA Research（2019）
    Historically, the long-held protein-centered bias has denoted 98% of the human genome as 'Junk' DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome...
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    Long Noncoding RNAs As Promising Biomarkers in Cancer
    Ozal Beylerli,Ilgiz Gareev,Albert Sufianov,Tatiana Ilyasova,Yang Guang
    Non-coding RNA Research（2022）
    Despite many advances in diagnosis and therapy (surgery, radiation therapy, chemotherapy), cancer remains one of the most important public health problems worldwide. Every day, the role of exosomes in cancer development and metastasis is being better described. Liquid biopsy was ...
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    Long non-coding RNAs as biomarkers and therapeutic targets for ischemic stroke
    Galina Sufianova,Alina Shumadalova,Wenhao Yao,Ilgiz Gareev
    Non-coding RNA Research（2022）
    Background: The problem of ischemic stroke (IS) has become increasingly important in recent years, as it ranks first in the structure of disability and mortality, crowding out other vascular diseases. In this regard, the study of this pathology and the search for new therapeutic ...
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    Potential Physiological Roles of the 31/32-Nucleotide Y4-RNA Fragment in Human Plasma
    Sho Ninomiya,Tatsuya Ishikawa,Masayuki Takahashi,Mineaki Seki,Masayuki Nashimoto
    Non-coding RNA Research（2019）
    The 31- and 32-nt 5'-fragments of Y4-RNA (Y4RNAfr) exist abundantly in human plasma. The Y4RNAfr can function as 5'-half-tRNA-type sgRNA for tRNase Z(L), although we do not know yet what its physiological roles are and what cellular RNAs are its genuine targets. In this paper, we...
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    DNM3OS/miR-127-5p/CDH11, Activates Wnt3a/β-catenin/LEF-1 Pathway to Form a Positive Feedback and Aggravate Spine Facet Joint Osteoarthritis
    Jing Wang, Zhenyu Yang, Xiuming He,Yeyang Wang,Dixin Luo,Wangyang Xu, Hongtao Zhang,Xiaozhong Zhou
    Non-coding RNA Research（2024）
    Spinal facet joint osteoarthritis (FJOA) is an OA disease with pathogenesis and progression uncovered. Our present study was performed to elucidate the role of DNM3OS on spinal FJOA. In this study, spine facet joint tissue of patients were collected. In vitro and in vivo models w...
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    Hotspots and Development Frontiers of Circrna Based on Bibliometric Analysis
    Chunlei Zhang,Yindong Kang,Feiyan Kong, Qi Yang,Dehui Chang
    Non-coding RNA Research（2022）
    Background and purpose:Circular RNAs (circRNAs) are a big group of members of the noncoding RNA family following long non-coding RNA and microRNA. They play a regulatory role in many biological processes. Analyzing their current research status and future development trends is co...
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    The Roles of Long Noncoding RNAs in Atrial Fibrillation
    Ozal Beylerli,Jiaming Ju,Aferin Beilerli,Ilgiz Gareev,Alina Shumadalova,Tatiana Ilyasova,Yunlong Bai,Baofeng Yang
    NON-CODING RNA RESEARCH（2023）
    Atrial fibrillation (AF) is a common cardiac arrhythmia that often occurs in patients with structural heart disease and is a significant cause of morbidity and mortality in clinical settings. AF is typically associated with significant changes of both the structure of the atria a...
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    Circulation Microrna Expression Profiles in Patients with Complete Responses to Chemoradiotherapy in Nasopharyngeal Carcinoma
    Tirta Wardana,Siti Nur Chasanah,Risky Oktriani,Cita Herawati,Sumadi Lukman Anwar,Indwiani Astuti,Sofia Mubarika Haryana
    Non-coding RNA Research（2022）
    Background: Nasopharyngeal carcinoma (NPC) is endemic cancer in Southeast Asia with a relatively poor prognosis. Chemoradiotherapy is a primary treatment that advantages certain patients, particularly in the early stages. New predictive and prognostic biomarkers are required to g...
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    The Y4-RNA Fragment, a Potential Diagnostic Marker, Exists in Saliva
    Tatsuya Ishikawa,Arisa Haino,Mineaki Seki,Hiroshi Terada,Masayuki Nashimoto
    Non-coding RNA Research（2017）
    The 94-nt full-length Y4-RNA is thought to have roles in the initiation of DNA replication and RNA quality control. Although its 31/32-nt fragment also exists abundantly in plasma, little is known about its physiological role. Since the 31/32-nt Y4-RNA fragment in sera is reporte...
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    Long Noncoding RNAs (lncrnas) in HIV-mediated Carcinogenesis: Role in Cell Homeostasis, Cell Survival Processes and Drug Resistance
    Lilian Makgoo,Salerwe Mosebi,Zukile Mbita
    NON-CODING RNA RESEARCH（2022）
    There is accruing data implicating long non-coding RNAs (lncRNAs) in the development and progression of noncommunicable diseases such as cancer. These lncRNAs have been implicated in many diverse HIV-host interactions, some of which are beneficial to HIV propagation. The virus-ho...
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    The Significance of Microrna Deregulation in Colorectal Cancer Development and the Clinical Uses As a Diagnostic and Prognostic Biomarker and Therapeutic Agent
    Alireza Ahadi
    NON-CODING RNA RESEARCH（2020）
    Colorectal cancer (CRC) is one of the most widely recognized and deadly malignancies worldwide. Although death rates have declined over the previous decade, mainly because of enhanced screening or potential treatment alternatives, CRC remains the third leading cause of cancer-rel...
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    The Role of Exosomal Lncrnas in Acetaminophen-Induced Induced Liver Injury in SD Rats
    Zixuan Yang, Lei Shi,Minhui Zheng, Minbo Hou, Mengdi Zhou, Naying Su, Hui Lang, Liyuan Zhao,Mengyun Gu,Naping Tang,Yan Chang
    NON-CODING RNA RESEARCH（2024）
    BackgroundDrug-induced liver injury (DILI) is a leading cause of drug development failures during clinical trials and post-market introduction. Current biomarkers, such as ALT and AST, lack the necessary specificity and sensitivity needed for accurate detection. Exosomes, which p...
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    Macro Roles for Micrornas in Neurodegenerative Diseases
    D. Rajgor
    NON-CODING RNA RESEARCH（2020）
    Neurodegenerative diseases (NDs) are typically adult-onset progressive disorders that perturb neuronal function, plasticity and health that arise through a host of one or more genetic and/or environmental factors. Over the last decade, numerous studies have shown that mutations i...
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    Exploring the Mechanisms Behind Long Noncoding RNAs and Cancer
    Maggie M. Balas,Aaron M. Johnson
    Non-coding RNA Research（2018）
    Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer types. The aberrant expression of these transcripts has been linked to tumor...
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    Long Non Coding RNAs and ALS: Still Much to Do
    Stella Gagliardi,Cecilia Pandini,Maria Garofalo,Matteo Bordoni,Orietta Pansarasa,Cristina Cereda
    Non-coding RNA Research（2018）
    Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and unde...
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    MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions
    Aisha M. ElKhouly,R. A. Youness,M. Z. Gad
    Non-coding RNA Research（2020）
    Despite historically known as "junk" DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration in their expression level has been reported to be directly associated wit...
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    Uncovering Pathways Regulating Chondrogenic Differentiation of CHH Fibroblasts
    Alzbeta Chabronova,Guus G. H. van den Akker, Mandy M. F. Meekels-Steinbusch,Franziska Friedrich,Andy Cremers,Don A. M. Surtel,Mandy J. Peffers,Lodewijk W. van Rhijn,Ekkehart Lausch,Bernhard Zabel,Marjolein M. J. Caron,Tim J. M. Welting
    Non-coding RNA Research（2021）
    Mutations in the non-coding snoRNA component of mitochondrial RNA processing endoribonuclease (RMRP) are the cause of cartilage-hair hypoplasia (CHH). CHH is a rare form of metaphyseal chondrodysplasia characterized by disproportionate short stature and abnormal growth plate deve...
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    Extracellular Vesicle Associated Long Non-Coding RNAs Functionally Enhance Cell Viability
    Chris Hewson,David Capraro,Jon Burdach,Noel Whitaker,Kevin V. Morris
    Non-coding RNA Research（2016）
    Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes inst...
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