Novel Plasma Biomarkers of Coronary Artery Calcium Incidence or Progression: Insights from the Prospective Multi-Ethnic Dallas Heart Study Cohort.
Atherosclerosis(2024)
摘要
Background and aims: Identifying the association of novel plasma biomarkers with coronary artery calcium (CAC) incidence or progression may provide insights into the pathophysiology of atherogenesis and plaque formation. Methods: Participants of the Dallas Heart Study (DHS), a multi -ethnic cohort of ambulatory individuals at lowintermediate risk for future atherosclerotic cardiovascular disease (ASCVD), who had their blood tested for 31 biomarkers reflecting multiple pathophysiological pathways, underwent 2 serial non-contrast computed tomography assessments for CAC a median similar to 7 years apart. The collected biomarkers were explored for association with CAC incidence or progression using univariate and multivariate analysis. Results: A total of 1424 participants were included; mean age 43 years, 39 % male, and nearly half AfricanAmerican. Over a 7 -year interval between the two CAC measurements, 340 participants (23.9 %) had CAC incidence or progression, 105 (7.4 %) with incident CAC, and 309 (21.7 %) with CAC progression. Although several plasma biomarkers were associated with CAC incidence or progression in a univariate model, only soluble intercellular adhesion molecule -1 (sICAM-1), related to atherosclerosis by the inflammatory pathway, remained independently associated in a multivariate model adjusted for traditional risk factors. Conclusions: Further studies are needed to characterize the role of sICAM-1 in CAC evolvement to establish whether it has a pivotal mechanistic contribution or is rather an innocent bystander. Alternate measures of coronary atherosclerosis may be needed to elucidate contributors to atherosclerosis incidence or progression.
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关键词
Coronary artery calcium,Biomarkers,Atherogenesis,Atherosclerosis,Atherosclerotic cardiovascular disease
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