Dr. Khera's main research focus is preventing cardiac disease. He has published over 200 academic articles on his findings.

Dr. Khera has been honored by the American Heart Association for cardiovascular research in women’s health and by the American College of Cardiology for his work in preventive cardiology. He was included in D Magazine's Best Doctors list from 2014-2023, and was also named a Texas Monthly Super Doctor from 2013-2023.