Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma
Clinical Immunology(2021)
Abstract
The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate to omentum and liver in OAC and contribute to inflammation in these tissues. Here, we assessed the tissue distribution and phenotype of gamma/delta (γδ) T cells in the blood, omentum, liver and tumour of OAC patients.
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Key words
Oesophageal adenocarcinoma,γδ T cells,Inflammation,Obesity,Omentum
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