Interleukin-6 signaling blockade exacerbates acute and late injury from focal intestinal irradiation.

Brett I Bell,Sravya Koduri,Carlo Salas Salinas,James Monslow,Ellen Puré,Edgar Ben-Josef,Constantinos Koumenis, Ioannis I Verginadis

International Journal of Radiation Oncology*Biology*Physics（2019）

引用 11|浏览22

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摘要

Focal irradiation of the intestine produced a significant increase in immune cells in the irradiated area as well as a systemic inflammation and anemia. Blockade of IL6 signaling was found to exacerbate acute intestinal injury as well as late intestinal injury after focal irradiation.

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关键词

Inflammation,Interleukin-6,Intestinal immune system,Radiation enteropathy,Radiation-induced fibrosis

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