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职业迁徙
个人简介
KEYWORDS:
Tumor Microenvironment, Tumor Metabolism, Integrated Stress Response, drug screens, radiosensitizers.
RESEARCH INTERESTS:
Delineation of mechanisms of resistance to tumor microenvironmental stress, with emphasis on the Unfolded Protein Response in cancer. Development of small molecule agents to target these mechanisms as novel targeted modalities. Development of novel radiosensitizers.
My laboratory is primarily interested in two broad areas:
1. To understand the mechanisms by which components of the microenvironment (e.g. hypoxia, low nutrient availability) interact with cellular survival/apoptotic pathways to produce a more resistant tumor phenotype. Once we understand the regulation and function of these survival pathways, we then design cell-based and assays to screen small molecule libraries for compounds that inhibit these processes and test them alone or in combination with genotoxic agents in several animal tumor models.
2. To increase the therapeutic effectiveness of ionizing radiation (IR) by either employing existing compounds with relatively safe toxicity profiles or employ screening strategies to identify novel and potent radiation sensitizers. We are also interested in developing novel delivery approaches for such compounds, such as biocompatible nanoparticles.
Tumor Microenvironment, Tumor Metabolism, Integrated Stress Response, drug screens, radiosensitizers.
RESEARCH INTERESTS:
Delineation of mechanisms of resistance to tumor microenvironmental stress, with emphasis on the Unfolded Protein Response in cancer. Development of small molecule agents to target these mechanisms as novel targeted modalities. Development of novel radiosensitizers.
My laboratory is primarily interested in two broad areas:
1. To understand the mechanisms by which components of the microenvironment (e.g. hypoxia, low nutrient availability) interact with cellular survival/apoptotic pathways to produce a more resistant tumor phenotype. Once we understand the regulation and function of these survival pathways, we then design cell-based and assays to screen small molecule libraries for compounds that inhibit these processes and test them alone or in combination with genotoxic agents in several animal tumor models.
2. To increase the therapeutic effectiveness of ionizing radiation (IR) by either employing existing compounds with relatively safe toxicity profiles or employ screening strategies to identify novel and potent radiation sensitizers. We are also interested in developing novel delivery approaches for such compounds, such as biocompatible nanoparticles.
研究兴趣
论文共 213 篇作者统计合作学者相似作者
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Scientific Reportsno. 1 (2024): 1-11
Fan Yang, Md Naushad Akhtar,Duo Zhang,Rakan El-Mayta, Junyoung Shin,Jay F Dorsey,Lin Zhang,Xiaowei Xu,Wei Guo, Stephen J Bagley,Serge Y Fuchs,Constantinos Koumenis,
Science advancesno. 9 (2024): eadj4678-eadj4678
Kyle Kim,Michele M Kim,Giorgos Skoufos,Eric S Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos,Khayrullo Shoniyozov,Joanna Griffin,Artemis G Hatzigeorgiou,James M Metz,
International journal of radiation oncology, biology, physics (2024)
Xiaohu Tang,Joseph E. Lucas,Julia Ling-Yu Chen,Gregory LaMonte,Jianli Wu, Michael Changsheng Wang,Constantinos Koumenis,Jen-Tsan Chi
crossref(2023)
Diane R. Fels,Jiangbin Ye, Andrew T. Segan, Steven J. Kridel,Michael Spiotto,Michael Olson,Albert C. Koong,Constantinos Koumenis
crossref(2023)
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