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Research Interests
Our contribution to precision medicine includes the invention of the AMP technology that has accelerated gene fusion discovery. Following initial clinical implementations in top U.S. hospitals (MSK Solid Fusion, MGH NGS Fusion, etc.), the AMP technology has been adopted globally for robust gene fusion detection to guide targeted therapies for cancer patients. We have also developed the GUIDE-seq method that has become a widely used reference for genome-wide unbiased profiling of CRISPR edits. Currently, we focus on:
Liquid biopsy – to identify molecular determinants and circulating signatures for cancer monitoring, diagnosis and, ultimately, prevention.
Precision genome editing – to improve CRISPR genome editing precision for treating diseases rooted in altered DNA bases or chromosomal structures.
Our contribution to precision medicine includes the invention of the AMP technology that has accelerated gene fusion discovery. Following initial clinical implementations in top U.S. hospitals (MSK Solid Fusion, MGH NGS Fusion, etc.), the AMP technology has been adopted globally for robust gene fusion detection to guide targeted therapies for cancer patients. We have also developed the GUIDE-seq method that has become a widely used reference for genome-wide unbiased profiling of CRISPR edits. Currently, we focus on:
Liquid biopsy – to identify molecular determinants and circulating signatures for cancer monitoring, diagnosis and, ultimately, prevention.
Precision genome editing – to improve CRISPR genome editing precision for treating diseases rooted in altered DNA bases or chromosomal structures.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
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Shifeng Lian,Chenyu Lu,Fugui Li,Xia Yu, Limei Ai,Biao-Hua Wu,Xueyi Gong, Wenjing Zhou,Xuejun Liang,Jiyun Zhan,Yong Yuan,Fang Fang,
Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Shifeng Lian,Chenyu Lu,Fugui Li,Xia Yu, Limei Ai,Biaohua Wu, Xueyi Gong, Wenjing Zhou, Yulong Xie,Yun Du, Wen Quan, Panpan Wang,
Shifeng Lian,Chenyu Lu,Fugui Li,Xia Yu, Limei Ai,Biaohua Wu, Xueyi Gong, Wenjing Zhou, Yulong Xie,Yun Du, Wen Quan, Panpan Wang,
CANCER RESEARCHno. 7 (2023)
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Cancer Researchno. 7_Supplement (2023): 2297-2297
MOLECULAR THERAPYno. 4 (2023): 281-281
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MOLECULAR THERAPYno. 4 (2023): 692-692
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MOLECULAR THERAPYno. 4 (2023): 575-576
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