基本信息
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职业迁徙
个人简介
Research
Drug Discovery
We are interested in developing drug leads/candidates for new targets including kinase, phosphate kinase and protein targets identified by UNC faculty and external investigators. We have successfully used the structure- and/or ligand-based drug design approaches to deliver compounds to clinic (MerTK inhibitors) or licensing (IDH1 inhibitor, co-developed with NCATs). We will continue to apply the similar approaches for drug discovery towards new targets.
Synthetic Methodology Development
Heterocyclic compounds are widely used in drug discovery as key pharmacophores. However, some are not readily available and are difficult to prepare in the variety and quantities needed for structure-activity relationship studies. We are currently interested in developing short, effective and robust synthetic routes for these heterocycles.
研究兴趣
论文共 164 篇作者统计合作学者相似作者
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Xingyao Li, Regan B. Kirkpatrick,Xiaodong Wang, Charles J. Tucker, Anuj Shukla,Henning J. Jessen,Huanchen Wang, Stephen B. Shears,Chunfang Gu
Cell Reportsno. 6 (2024): 114316
Deyu Kong, Qiang Tian,Zhilong Chen,Hongchao Zheng,Michael A. Stashko,Dan Yan,H. Shelton Earp, Stephen V. Frye,Deborah Deryckere,Dmitri Kireev,Douglas K. Graham,Xiaodong Wang
JOURNAL OF MEDICINAL CHEMISTRYno. 7 (2024): 5866-5882
Yubai Zhou, Pratima Chapagain,Desmarini Desmarini, Dilipkumar Uredi, Lucia E. Rameh,Julianne T. Djordjevic,Raymond D. Blind,Xiaodong Wang
biorxiv(2024)
Journal of medicinal chemistryno. 7 (2024): 5866-5882
Sandra Christoph,Deborah DeRyckere, Jennifer Schlegel,J. Kimble Frazer, Lance A. Batchelor, Alesia Y. Trakhimets, Susan Sather,Debra M. Hunter, Christopher T. Cummings,Jing Liu,Chao Yang,Dmitri Kireev,
crossref(2023)
Yan Kai Zhong, Xixi Tan,Xiaodong Wang, Jun Jiang, Kai Shu, Haiyuan Chen,Hao Zhang,Zuoyun Wang,Lei Zhang, Chunming Guo,Hongfeng Liang,Wei Yu
Journal of Biochemical and Molecular Toxicology (2023)
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PNAS nexusno. 2 (2023)
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