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个人简介
Dr. Jefferies’ current research program focuses on discovering and translating new therapies for disease. His current interests are in tumour immunology and cancer immunotherapy; antigen presentation and vaccines; and blood-brain barrier and angiogenesis. His work on cancer targets the restoration of the immune system’s ability to recognize tumours that have lost functional antigen processing machinery components, which may render selected tumours “invisible” to adaptive immune responses. His team is also utilizing novel screening systems to identify genes, proteins and small molecules that are able to restore and enhance immune recognition and killing of cancer cells. Notably, with other Vancouver Prostate Centre colleagues, Dr. Jefferies is leading an initiative to examine the use of IL-33 as an immune-biomarker for metastatic prostate tumours and a prognosticator for recurrence of prostate cancer in patients.
研究兴趣
论文共 209 篇作者统计合作学者相似作者
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biorxiv(2024)
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Clara Wenjing Xia,Iryna Saranchova, Pablo L Finkel, Stephanie Besoiu,Lonna Munro,Cheryl G Pfeifer,Anne Haegert,Yen-Yi Lin,Stéphane Le Bihan,Colin Collins,Wilfred A Jefferies
Communications biologyno. 1 (2024): 12-12
Chaahat S B Singh, Kelly Marie Johns,Suresh Kari,Lonna Munro, Angela Mathews,Franz Fenninger,Cheryl G Pfeifer,Wilfred A Jefferies
Stem cell reports (2024)
Chaahat S.B. Singh, Kelly Marie Johns,Suresh Kari,Lonna Munro, Angela Mathews,Franz Fenninger,Cheryl G. Pfeifer,Wilfred A. Jefferies
Stem Cell Reports (2024)
Iryna Saranchova,Clara Wenjing Xia, Stephanie Besoiu, Pablo L. Finkel, Samantha L. S. Ellis,Suresh Kari,Lonna Munro,Cheryl G. Pfeifer,Ladan Fazli,Martin E. Gleave,Wilfred A. Jefferies
FRONTIERS IN IMMUNOLOGY (2024): 1317522-1317522
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Research Square (Research Square) (2023)
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crossref(2023)
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