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个人简介
The research focus of Dr. Xie's laboratory is nuclear receptor-mediated transcriptional regulation of genes that encode drug metabolizing enzymes and drug transporters. In addition to metabolizing drugs, the same enzyme and transporter systems are also responsible for the homeostasis of numerous endobiotic molecules. Therefore, besides drug metabolism and disposition, this regulation has broad implications in many human diseases, including liver diseases (fatty liver, liver fibrosis, liver cancer, and autoimmune hepatitis), endocrine disorders, metabolic syndrome, and cancers. Dr. Xie’s research is conducted using a combination of cell cultures and genetically engineered mice that include tissue and cell type-specific transgenic, knockout and humanized mice.
研究兴趣
论文共 296 篇作者统计合作学者相似作者
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Shaoxing Guan,Xi Chen, Yuru Wei, Fei Wang,Wen Xie,Youhao Chen,Heng Liang,Xia Zhu,Yunpeng Yang,Wenfeng Fang,Yan Huang,Hongyun Zhao,
Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Acta Pharmaceutica Sinica Bno. 4 (2024): 1711-1725
Ting Yang,Kang Chao,Xia Zhu,Xue-Ding Wang, Sumyuet Chan,Yan-Ping Guan,Jing Mao, Pan Li,Shao-Xing Guan,Wen Xie,Xiang Gao,Min Huang
STEROIDS (2024): 109335-109335
Zhangyi Luo,Zhuoya Wan, Pengfei Ren, Bei Zhang,Yixian Huang,Raymond E West,Haozhe Huang,Yuang Chen,Thomas D Nolin,Wen Xie,Junmei Wang,Song Li,
Advanced science (Weinheim, Baden-Wurttemberg, Germany)pp.e2307940-e2307940, (2024)
Hepatology internationalno. 5 (2023): 1150-1161
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The Journal of biological chemistryno. 3 (2023): 103026-103026
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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HEPATOLOGY (2023): S1114-S1114
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