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Breast cancer has been the focus of my research in the last 25 years. Specifically, I have concentrated on the investigation of biological markers as prognostic and predictive factors for response to therapy. The technology I used was predominantly immunohistochemistry and in situ hybridization. However, in certain areas, molecular biology, particularly PCR was used. The biological markers included hormone receptors, Her2/neu oncogene and many molecular markers that are involved in angiogenesis and may play a possible role in invasiveness.
As part of my research activities in breast is tumour banking and databases.
I have coordinated with Dr. Steven Narod the Henrietta Banting Breast Cancer database which includes 2,000 patients which are annotated with clinical outcomes. Many of the biological markers that are done are continuously added to the database. This group of patient have also been put into TMAs that are available for continuous testing.
A second tumour bank includes 5,000 frozen breast cancer cases which have basic information attached to it.
The third database is in collaboration with Dr. Zubovits and Dr. Nofech-Mozes and we have established a database of 10,000 from 2000 to present which includes every patient that was tested for Her2/neu oncoprotein. The database includes basic pathological information as well as estrogen and progesterone receptor status.
We have created various subsets of TMAs to test new biological markers and currently we are testing p10 and Her3 on these subsets. We are also participating in multiple ring studies for various biological markers.
I have also been involved in the standardization of testing for molecular markers for breast cancer and have been involved in setting guidelines locally as well as nationally and internationally, specifically for hormone receptors and Her2/neu testing.
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Journal of Clinical Pathologypp.jcp-2022, (2023)
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