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The aim of our research is the development of new and better optical methods for the biomedical research. One of our successes is the co-development of the Multiple-Photon-Excitation-Microscope. This microscope reduces the strong diffusion of light, which is especially prominent in brain tissue, and which limits the use of conventional light microscopes. A further success is the development of the Serial Block Face Scanning Electron Microscopy: In an automated process, an electron microscope scans the surface of a tissue sample and saves the resulting picture. Next, the device removes an ultra-thin tissue slice and again scans the now novel surface of the sample. In this way, a tissue sample is scanned level for level before it is reassembled at the computer into a 3D image of the original sample. This is an optimal starting point to investigate the network structure and individual nerve cell connections of the brain.
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Michał Januszewski,Jörgen Kornfeld,Peter H. Li,Art Pope, Tim Blakely, Larry Lindsey,Jeremy Maitin-Shepard,Mike Tyka,Winfried Denk,Viren Jain
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