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个人简介
Vicente Felipo is the Head of the Laboratory of Neurobiology and Director of the Program on Neurological Impairment at the Centro Investigacion Principe Felipe. Valencia.
Dr. Felipo obtained his Ph.D degree in Biochemistry from the University of Valencia in 1983 under the direction of Prof. Santiago Grisolia. In 1990 he created the Laboratory of Neurobiology at Centro de Investigacion Principe Felipe. The Laboratory performs basic and translational research on the mechanisms, diagnosis and treatment of neurologic (cognitive, motor, in sleep and circadian rhythms) impairment in different pathological situations, with main focus on hepatic encephalopathy. They study in animal models the molecular mechanisms responsible for the neurological alterations in patients with hepatic encephalopathy (HE). Once identified the molecular alteration, they try to restore normal cerebral and neurological function through pharmacological treatments. These studies allowed them to 1) prevent death induced by acute ammonia intoxication; 2) prevent or delay death in rats with acute liver failure; 3) restore learning ability and 4) reverse hypokinesia in rats with chronic HE. In parallel studies they assess the neurologic and cerebral alterations in patients with liver cirrhosis and minimal HE (MHE) and underlying mechanisms and look for new diagnostic procedures. They have identified 3-nitrotyrosine as the first good indicator for early MHE diagnosis, which will allow generalization of MHE diagnosis and treatment.
研究兴趣
论文共 376 篇作者统计合作学者相似作者
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Marta Llansola,Yaiza M. Arenas, Maria Sancho-Alonso, Gergana Mincheva, Andrea Palomares-Rodriguez, Magnus Doverskog,Paula Izquierdo-Altarejos,Vicente Felipo
Extracellular Vesicles and Circulating Nucleic Acidspp.37-43, (2024)
Juan José Gallego-Roig,Alessandra Fiorillo,Franc Casanova-Ferrer,Amparo Urios, Vicente Roig,María Pilar Ballester,Lucía Durbán,María Pilar Rios,Andrea Cabrera‐Pastor,Javier Megías,Teresa San-Miguel,Salvador Benlloch,
The American Journal of Gastroenterologyno. 9S (2023): S10-S11
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EXPERT OPINION ON INVESTIGATIONAL DRUGSpp.1-15, (2023)
International Journal of Molecular Sciencesno. 24 (2023): 17251
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