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个人简介
We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.
Springer discovered with monoclonal antibodies, then cloned and functionally and structurally characterized, many of the adhesion receptors in the immune system. He was the first to demonstrate that lymphocytes and leukocytes had adhesion molecules. His work on these receptors has advanced to characterizing their interactions and allosteric transitions by x-ray crystallography, electron microscopy, and laser tweezers force spectroscopy.
Springer’s academic interests now focus on how protein conformational change together with tensile force activates integrins, von Willebrand factor, the transforming growth factor-b family, and adhesins on malaria sporozoites, and discovering new binding partners. Springer has over 500 publications, a Hirsch index of 147, and over 30 patents. He is a member of the National Academy of Sciences and his honors include the Crafoord Prize, the American Association of Immunologists Meritorious Career Award, and the Stratton Medal from the American Society of Hematology.
Springer is an investor in Selecta Bioscience since its B round and a founding investor in Moderna Therapeutics. He is a Resident Professor at Pfizer. He is founder and investor in Scholar Rock and in Morphic Rock Therapeutics, and board member and lead angel of Ab Initio Biotherapeutics. As a philanthropist, Springer has endowed Chairs at Harvard Medical School and Children’s Hospital, and is on the Children’s Hospital Boston Board of Trust.
Current projects include a non-profit to advance entrepeneurship and innovation in protein therapeutics and open-source antibodies and small molecules. Next is a dual-acting malaria vaccine, to both protect humans from being infected, and to prevent mosquitos from transmitting infection.
研究兴趣
论文共 38 篇作者统计合作学者相似作者
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Friedrich Braumann,Dennis Klug,Jessica Kehrer,Gaojie Song,Juan Feng,Timothy A Springer,Friedrich Frischknecht
EMBO reportsno. 7 (2023)
Anindya Roy,Lei Shi,Ashley Chang,Xianchi Dong,Andres Fernandez,John C. Kraft,Jing Li,Viet Q. Le, Rebecca Viazzo Winegar,Gerald Maxwell Cherf, Dean Slocum,P. Daniel Poulson,
NATURE COMMUNICATIONSno. 1 (2023)
Viet Q. Le,Bo Zhao, Siddanth Ramesh, Cameron Toohey, Adam DeCosta,Julian Mintseris,Xinyue Liu,Steven Gygi,Timothy A. Springer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 24 (2023)
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Viet Q. Le,Roxana E. Iacob,Bo Zhao,Yang Su,Yuan Tian, Cameron Toohey,John R. Engen,Timothy A. Springer
biorxiv(2022)
Cellno. 19 (2022): 3533-3550.e27
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