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Vertebrate genomes encode hundreds of proteolytic enzymes that act on the surface of cells to regulate a range of biological processes. When missing or inappropriately regulated, these proteolytic enzymes also play a critical role in the development and progression of many important human diseases. The goal of Dr. Bugge’s research is to understand the biochemistry, biology, and pathology of cell-surface proteolytic enzymes. His team is particularly interested in determining their contribution to the development, regeneration, and malignant transformation of oral tissues. He and his colleagues also work on exploiting the detailed knowledge of protease expression in human cancer—generated from basic research studies—to develop novel tumor protease-activated pro-drugs for cancer therapy.
Dr. Bugge has received several NIH and international awards for his research, mentoring, and service to the scientific community, including the 2012 International Society for Fibrinolysis and Proteolysis Prize for "Outstanding Contributions to the Field of Fibrinolysis, Thrombolysis and Proteolysis," and the 2016 NIH Director’s Ruth L. Kirschstein Mentoring Award “For exemplary performance while demonstrating significant leadership, skill and ability in serving as a mentor. “
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论文共 182 篇作者统计合作学者相似作者
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Elodie Ehret, Sevan Stroh, Muriel Auberson,Frederique Ino, Yannick Jager,Marc Maillard,Roman Szabo,Thomas H. Bugge,Simona Frateschi,Edith Hummler
CELLSno. 19 (2023): 2342-2342
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The Journal of experimental medicineno. 9 (2023)
引用7浏览0WOS引用
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Development (Cambridge, England)no. 17 (2023)
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Donald R. Schwartz,Kamiar Moin, Bin Yao,Lynn M. Matrisian,Lisa M. Coussens,Thomas H. Bugge,Barbara Fingleton, Heath B. Acuff, Mark Sinnamon, Hind Nassar,Adrian E. Platts,Stephen A. Krawetz,
crossref(2023)
Yunpeng Su, Janelle Ortiz,Shihui Liu,Thomas H. Bugge,Ravibhushan Singh, Stephen H. Leppla,Arthur E. Frankel
crossref(2023)
Zehua Zuo,Jie Liu,Zhihao Sun, Rachel Silverstein,Meijuan Zou,Toren Finkel,Thomas H Bugge,Stephen H Leppla,Shihui Liu
PNAS nexusno. 3 (2022): pgac104-pgac104
Carly Merritt, Elizabeth M. Chun,Rasem J. Fattah,Lakmali M. Silva, Quinn Q. Ma,Mahtab Moayeri,Dennis Paliga,Sebastian Neumann,Rolf Heumann,Stephen H. Leppla,Thomas H. Bugge
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