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The primary goal of our lab is to understand the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer. The lab has three primary areas of interest: analyzing the role of developmental signals in stem cells and cancer, defining mechanisms that initiate stem cell regeneration after injury and developing high-resolution imaging strategies to visualize the behavior of living stem cells during growth, regeneration, and can¬cer formation. These studies have implications not only for understanding the basic mechanisms that regulate normal and oncogenic self-renewal, but also for enhancing stem cell based therapies for human disease.
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论文共 112 篇作者统计合作学者相似作者
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Cold Spring Harbor perspectives in medicine (2024)
CANCER CELLno. 11 (2023): 1989-+
bioRxiv : the preprint server for biology (2023)
Mitch Biermann, Cynthia Quintero,Paige Ferguson,Nirakar Rajbhandari,Donglim Esther Park,Hitendra Patel,Tannishtha Reya
Michelle Kameda-Smith, Helen Zhu,EnChing Luo,Chitra Venugopal, Agata Xella,Brian Yee,Sansi Xing,Frederick Tan,Raymond Fox, Kevin Brown,Ashley Adile,David Bakhshinyan,
Research Square (Research Square) (2022)
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