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Dr. Tamara O’Connor is an Assistant Professor in the Department of Biological Chemistry at the Johns Hopkins University School of Medicine. She received Ph.D. in Biochemistry from McMaster University, Canada. Dr. O’Connor completed her postdoctoral work in Microbial Pathogenesis at Tufts University School of Medicine.
The O'Connor lab studies the molecular basis of infectious disease with a particular emphasis on the network of molecular interactions acting at the host-pathogen interface. Using Legionella pathogenesis as a model system, we are defining the various mechanisms by which an intracellular bacterial pathogen can establish infection, how they exploit host cell machinery to accomplish this, and how individual proteins and their component pathways coordinately contribute to disease. In parallel, we investigate how virulence strategies arise in environmental reservoirs as a consequence of bacterial interactions with protozoa and the role of these natural hosts in driving bacterial transmission and disease in humans. Using genetics and functional genomics, we examine the repertoires of virulence proteins required for growth in a broad assortment of hosts, how the network of molecular interactions differs between hosts, and the mechanisms by which bacterial pathogens cope with this variation.
The O'Connor lab studies the molecular basis of infectious disease with a particular emphasis on the network of molecular interactions acting at the host-pathogen interface. Using Legionella pathogenesis as a model system, we are defining the various mechanisms by which an intracellular bacterial pathogen can establish infection, how they exploit host cell machinery to accomplish this, and how individual proteins and their component pathways coordinately contribute to disease. In parallel, we investigate how virulence strategies arise in environmental reservoirs as a consequence of bacterial interactions with protozoa and the role of these natural hosts in driving bacterial transmission and disease in humans. Using genetics and functional genomics, we examine the repertoires of virulence proteins required for growth in a broad assortment of hosts, how the network of molecular interactions differs between hosts, and the mechanisms by which bacterial pathogens cope with this variation.
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论文共 15 篇作者统计合作学者相似作者
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Soma Ghosh, Saumya Bandyopadhyay,Danielle M. Smith,Sangeeta Adak,Clay F. Semenkovich, Laszlo Nagy,Michael J. Wolfgang,Tamara J. O'Connor
PLOS PATHOGENSno. 2 (2024): e1011996-e1011996
David Boamah,Michael C. Gilmore,Sarah Bourget, Anushka Ghosh, Mohammad J. Hossain,Joseph P. Vogel,Felipe Cava,Tamara J. O'Connor
Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2023)
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017): 467-467
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