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I spent four years in the group of Professor Nobuhiro Go at the Department of Chemistry, University of Kyoto, Japan, and a further four years in the group of Professor Herman Berendsen at the Department of Chemistry, University of Groningen, The Netherlands. These postdoctoral positions were funded by personal fellowships: a Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship, a European Commission Science and Technology Programme Fellowship for Japan, and a European Commission's Biotechnology Programme Fellowship.
The general area of my research concerns conformational change in proteins and protein structure. In particular I am interested in the relationship between the two. We use various computational methods including, biogeometry, molecular dynamics simulation, and bioinformatics based approaches.
A main focus concerns domain motions in enzymes. Using molecular dynamics simulation we have shown that for some enzymes a domain-locking mechanism operates which keeps domains open in the absence of a functional ligand. The exact nature and purpose of the locking mechanism in alcohol dehydrogenase was elucidated recently.
The general area of my research concerns conformational change in proteins and protein structure. In particular I am interested in the relationship between the two. We use various computational methods including, biogeometry, molecular dynamics simulation, and bioinformatics based approaches.
A main focus concerns domain motions in enzymes. Using molecular dynamics simulation we have shown that for some enzymes a domain-locking mechanism operates which keeps domains open in the absence of a functional ligand. The exact nature and purpose of the locking mechanism in alcohol dehydrogenase was elucidated recently.
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The protein journalno. 3 (2023): 181-191
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