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Dr. Abcouwer's research is aimed at understanding various mechanisms/processes that contribute to the development of diabetic retinopathy, including neural degeneration, vascular dysfunction, and the function and activation of immune cells. He serves on the Juvenile Diabetes Research Foundation Diabetic Retinopathy Center leadership team. He is Co-Principal Investigator of the Preclinical Interventions Study (Project 2) of the Center along with Dr. David Antonetti. Together, they are examining the potential of various FDA-approved drugs to inhibit neurodegeneration and vascular dysfunction caused by retinal ischemia-reperfusion injury (IR), as well as diabetic retinopathy. Their research team has developed an innovative and efficient process of pre-screening in the IR model to identify treatments to be further tested in diabetic animals. IR serves as a useful tool to acutely model retinal neurodegeneration, as well as the vascular endothelial growth factor- (VEGF) dependent retinal vascular permeability. Having identified several promising drugs, they are now focusing on the mechanisms by which limited classes of drugs provide neuroprotection and/or alleviate the vascular permeability response to IR.
Dr. Abcouwer's research is aimed at understanding various mechanisms/processes that contribute to the development of diabetic retinopathy, including neural degeneration, vascular dysfunction, and the function and activation of immune cells. He serves on the Juvenile Diabetes Research Foundation Diabetic Retinopathy Center leadership team. He is Co-Principal Investigator of the Preclinical Interventions Study (Project 2) of the Center along with Dr. David Antonetti. Together, they are examining the potential of various FDA-approved drugs to inhibit neurodegeneration and vascular dysfunction caused by retinal ischemia-reperfusion injury (IR), as well as diabetic retinopathy. Their research team has developed an innovative and efficient process of pre-screening in the IR model to identify treatments to be further tested in diabetic animals. IR serves as a useful tool to acutely model retinal neurodegeneration, as well as the vascular endothelial growth factor- (VEGF) dependent retinal vascular permeability. Having identified several promising drugs, they are now focusing on the mechanisms by which limited classes of drugs provide neuroprotection and/or alleviate the vascular permeability response to IR.
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Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish,Dejuan Kong, Sumathi Shanmugam, Xuan An Le,Jingyu Yao, Heather Hager,David N Zacks
Journal of Neuroinflammationno. 1 (2024): 1-22
Experimental Eye Research (2023): 109653-109653
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