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Conventional fluorescence microscopy is limited by the diffraction of light: fluorescent objects that are close together cannot be discerned. Stimulated emission depletion (STED) is a recent advancement in optical physics that breaks the diffraction barrier, allowing microscopes to obtain much clearer images.
The diffraction barrier has been particularly problematic for imaging synaptic vesicles, which are among the smallest known organelles (30-50 nm in diameter). They are located in small areas in the synapses (about 1 micron in diameter). The group takes advantage of the increased imaging resolution provided by STED to investigate synaptic vesicle function, with an emphasis on synaptic vesicle recycling. Since STED microscopy also allows imaging of protein domains, the group aims at studying the patterning of protein domains in the synapse, in order to understand its molecular architecture.
Conventional fluorescence microscopy is limited by the diffraction of light: fluorescent objects that are close together cannot be discerned. Stimulated emission depletion (STED) is a recent advancement in optical physics that breaks the diffraction barrier, allowing microscopes to obtain much clearer images.
The diffraction barrier has been particularly problematic for imaging synaptic vesicles, which are among the smallest known organelles (30-50 nm in diameter). They are located in small areas in the synapses (about 1 micron in diameter). The group takes advantage of the increased imaging resolution provided by STED to investigate synaptic vesicle function, with an emphasis on synaptic vesicle recycling. Since STED microscopy also allows imaging of protein domains, the group aims at studying the patterning of protein domains in the synapse, in order to understand its molecular architecture.
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Life science allianceno. 1 (2024)
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Nikolaos Mougios, Elena R. Cotroneo, Nils Imse, Jonas Setzke,Silvio Rizzoli,Nadja A. Simeth,Roman Tsukanov,Felipe Opazo
biorxiv(2024)
CHEMICAL SCIENCEno. 9 (2024): 3311-3322
bioRxiv (Cold Spring Harbor Laboratory) (2023)
iScienceno. 2 (2023): 105971-105971
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Christian Hoffmann,Jakob Rentsch,Taka A Tsunoyama, Akshita Chhabra, Gerard Aguilar Perez,Rajdeep Chowdhury, Franziska Trnka, Aleksandr A Korobeinikov, Ali H Shaib,Marcelo Ganzella,Gregory Giannone,Silvio O Rizzoli,
Danieelle de Jong-Bolm,Mohsen Sadeghi,Cristian A. Bogaciu,Guobin Bao, Gabriele Klaehn,Merle Hoff, Lucas Mittelmeier,F. Buket Basmanav,Felipe Opazo,Frank Noe,Silvio O. Rizzoli
PLOS BIOLOGYno. 12 (2023)
Rodica Pena,Sarah L. Bluhm, Silke Ammerschubert,Paola Agüi-Gonzalez,Silvio O. Rizzoli,Stefan Scheu,Andrea Polle
Communications Biologyno. 1 (2023): 1-10
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