基本信息
浏览量:18
职业迁徙
个人简介
Research Description
We develop computer models for biomolecular structure and function with focus on RNA molecules. Biological molecules are large organic molecules composed of hundreds or thousands of atoms bound together by covalent bonds into a chain-like structure. One of the best known challenges in biology is to understand how biomolecules fold properly into compact structures to perform biological functions and how they misfold to cause disease. We develop computational methods to study RNA folding, predict RNA 3D structures, and model RNA-small molecule and RNA-metal ion interactions, RNA in vivo folding kinetics, and cellular functions at the level of gene expression and regulation. Furthermore, through collaborations with experimental labs, we design RNA-based therapeutic strategies involving aptamer binding and CRISPR-Cas9 gene editing.
We develop computer models for biomolecular structure and function with focus on RNA molecules. Biological molecules are large organic molecules composed of hundreds or thousands of atoms bound together by covalent bonds into a chain-like structure. One of the best known challenges in biology is to understand how biomolecules fold properly into compact structures to perform biological functions and how they misfold to cause disease. We develop computational methods to study RNA folding, predict RNA 3D structures, and model RNA-small molecule and RNA-metal ion interactions, RNA in vivo folding kinetics, and cellular functions at the level of gene expression and regulation. Furthermore, through collaborations with experimental labs, we design RNA-based therapeutic strategies involving aptamer binding and CRISPR-Cas9 gene editing.
研究兴趣
论文共 81 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
bioRxiv : the preprint server for biology (2024)
crossref(2024)
European journal of medicinal chemistry (2023): 115213-115213
European Journal of Medicinal Chemistry (2023): 115424-115424
Journal of advanced research (2022): 175-190
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn