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Gerecht’s research group studies the interactions between stem cells and their microenvironments with the long-term goal of engineering artificial cell microenvironments capable of guiding vascular differentiation, delivery, and regeneration. Her research program is based on the integrated and advanced use of tissue engineering system components and is grounded in the fundamentals of interfacial science and engineering and stem cell biology.
Gerecht pioneered the use of engineering fundamentals to understand and harness vascular fate decisions of stem cells, leading to both basic knowledge and future therapeutics. Her lab was the first to design/develop/engineer biomaterials to guide vascular morphogenesis through activation of cellular pathways required for vacuole formation and merging into large lumen, sprouting, and eventual network formation. In the area of hypoxia, her group developed a hydrogel to better control variations in oxygen levels. Her work has led to the establishment of a novel line of research dedicated to understanding how dissolved oxygen regulates stem cell differentiation and cancer growth.
Gerecht pioneered the use of engineering fundamentals to understand and harness vascular fate decisions of stem cells, leading to both basic knowledge and future therapeutics. Her lab was the first to design/develop/engineer biomaterials to guide vascular morphogenesis through activation of cellular pathways required for vacuole formation and merging into large lumen, sprouting, and eventual network formation. In the area of hypoxia, her group developed a hydrogel to better control variations in oxygen levels. Her work has led to the establishment of a novel line of research dedicated to understanding how dissolved oxygen regulates stem cell differentiation and cancer growth.
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Zhao Wei,Meng Lei,Yaohui Wang, Yizhou Xie,Xueyong Xie, Dongwei Lan,Yuanbo Jia,Jingyi Liu,Yufei Ma,Bo Cheng,Sharon Gerecht,Feng Xu
Nature Communicationsno. 1 (2024): 1-1
Avery T Tran,Emily O Wisniewski,Panagiotis Mistriotis,Konstantin Stoletov,Maria Parlani, Alice Amitrano, Brent Ifemembi,Se Jong Lee,Kaustav Bera,Yuqi Zhang,Soontorn Tuntithavornwat,Alexandros Afthinos,
Research square (2024)
Gloria E. Marino-Bravante,Alexis E. Carey,Laura Hüser, Agrani Dixit,Vania Wang,Amanpreet Kaur, Ying Liu, Supeng Ding,Rahel Schnellmann,Sharon Gerecht, Luo Gu,T. S. Karin Eisinger-Mathason,
biorxiv(2024)
Physiologyno. S1 (2024)
Arteriosclerosis, thrombosis, and vascular biologyno. 8 (2023): E291-E302
NATURE CARDIOVASCULAR RESEARCHno. 8 (2023): 718-732
Alexa R. Anderson, Eleanor L. P. Caston, Lindsay Riley, Long Nguyen,Dimitris Ntekoumes,Sharon Gerecht,Tatiana Segura
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Zhao Wei, Meng Lei,Yaohui Wang, Yizhou Xie,Xueyong Xie, Dongwei Lan,Yuanbo Jia,Jingyi Liu,Yufei Ma,Bo Cheng,Sharon Gerecht,Feng Xu
Nature Communicationsno. 1 (2023): 8307-8307
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