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个人简介
Dr. Ballinger’s group hypothesizes that mitochondrial – nuclear genetic interaction processes significantly influence common disease development. Because the genetic selection processes for mitochondrial – nuclear interaction are influenced by survival and reproductive success, the changing environmental challenges from original prehistoric conditions to contemporary (along with increased lifespan) have significantly affected cell function. In this regard, his work explores the influence of “mito-Mendelian” genetics upon bioenergetics, inflammation, metabolism, and nuclear gene expression. For these studies, he invented and has developed the Mitochondrial – Nuclear eXchange (MNX) model that enables unambiguous testing of mitochondrial and nuclear genetic backgrounds upon cell function and disease development. From this research, it is becoming clear that “mito-Mendelian” genetics influences cell function and response to acute and chronic stimuli. Consequently, the genetic basis for disease is not based solely upon Mendelian nor Mitochondrial genetics, but is the consequence of “mito-Mendelian” genetics. This concept is paradigm challenging. Current laboratory projects investigate the role for mito-Mendelian genetics upon various metabolic diseases (cancer, cardiovascular, ulcerative colitis and obesity).
AWARDS/HONORS:
Alexander Hollaender Distinguished Fellowship: U.S. Department of Energy
Environmental Pathology Fellowship: University of Vermont-NIH
Young Investigator Award: American Lung Association: New Hampshire-Vermont
Burroughs-Wellcome Nominee: University of Vermont
Outstanding Faculty Award, Molecular and Cellular Pathology Graduate Students
College of Science Academy of Distinguished Former Students Award, Texas A&M University
研究兴趣
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Cancer Researchno. 12_Supplement (2022): 2103-2103
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