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To make and organize different tissues, cells must decipher information from developmental signalling pathways. Currently we know little about how the information is encoded and decoded, to generate the right balance and arrangements of cell types. Cells face the challenge of transmitting this information accurately, so that cell-surface signals are translated into correct transcriptional responses. How this is achieved mechanistically remains a major question.
In our research we use a combination of live-imaging, genetic, biochemical and genomic approaches in Drosophila and in human cells to discover the fundamental mechanisms that reset and sculpt transcriptional responses to Notch. These mechanisms are essential to bring about different outcomes and to avoid inappropriate gene expression programmes being turned on.
In our research we use a combination of live-imaging, genetic, biochemical and genomic approaches in Drosophila and in human cells to discover the fundamental mechanisms that reset and sculpt transcriptional responses to Notch. These mechanisms are essential to bring about different outcomes and to avoid inappropriate gene expression programmes being turned on.
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论文共 146 篇作者统计合作学者相似作者
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F Javier DeHaro-Arbona, Charalambos Roussos, Sarah Baloul, Jonathan Townson,María J Gómez Lamarca,Sarah Bray
eLife (2024)
LIFE SCIENCE ALLIANCEno. 3 (2023)
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D-Core
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