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Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra’s group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra’s group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.
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Vincent Provasek,Albino Bacolla, Suganya Rangaswamy,Joy Mitra,Manohar Kodavati, Issa Yusuf,Vikas Malojirao,Velmarini Vasquez, Gavin W Britz, Guo-Min Li, Zuoshang Xu,Sankar Mitra,
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ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 9-10
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