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The Grevengoed group is interested in a novel class of lipids known as n-acyl taurines (NATs). As a conjugate of a fatty acid and taurine, these amphiphilic lipids are excellent, endogenously produced detergents. Dr. Grevengoed has previously revealed a role of these metabolites in cell signaling through GPR119 and in fat absorption. Through my experience in metabolomics, I aided in her studies of the kinetics of NAT metabolism and revealed that NATs are a biliary lipid class whose concentration increases with dietary fish oil to comparable levels of bile acids. While continuing to improve NAT analytical methods, we are uncovering how NATs are synthesized, localized to bile and how NATs cause fat malabsorption.
In parallel with my work on n-acyl taurine biology, I am interested in appetite regulation. Fibroblast growth factor 21 (FGF21) is a macronutrient responsive hepatokine known to regulate lipid metabolism and macronutrient preference. Circulating FGF21 increases in response to carbohydrates, protein restriction and alcohol ingestion. In converse, high protein diets blunt FGF21 in the presence of its secretagogues. How these macronutrient signals integrate to regulate hepatic FGF21 remains poorly understood. Using mass spectrometry based metabolomics, I am uncovering a relationship between small molecule metabolites and FGF21.
In parallel with my work on n-acyl taurine biology, I am interested in appetite regulation. Fibroblast growth factor 21 (FGF21) is a macronutrient responsive hepatokine known to regulate lipid metabolism and macronutrient preference. Circulating FGF21 increases in response to carbohydrates, protein restriction and alcohol ingestion. In converse, high protein diets blunt FGF21 in the presence of its secretagogues. How these macronutrient signals integrate to regulate hepatic FGF21 remains poorly understood. Using mass spectrometry based metabolomics, I am uncovering a relationship between small molecule metabolites and FGF21.
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论文共 41 篇作者统计合作学者相似作者
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The EMBO journalno. 3 (2024): 362-390
npj Agingno. 1 (2023): 1-21
Carmen Saenz, Qing Fang,Thiyagarajan Gnanasekaran,Samuel Addison Jack Trammell, Jesse Arnold Buijink,Paola Pisano,Michael Wierer,Frederic Moens, Bettina Lengger,Asker Brejnrod,Manimozhiyan Arumugam
MICROBIOLOGY SPECTRUMno. 5 (2023): e0393322-e0393322
Amalie Lanng,Laerke Gasbjerg, Andrea Sucksdorff,Jens Svenningsen,Samuel Trammell,Tina Vilsboll,Matthew Gillum,Filip Krag Knop
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Social Science Research Network (2022)
Emilie E. Christensen,Katrine D. Galsgaard, Christian D. Johansen,Samuel Trammell, Anna B. Bomholt, Jenna Hunt,Thomas Kruse, Jesper F. Lau,Trisha Grevengoed,Jens J. Holst,Nicolai J. Wewer Albrechtsen
Cell metabolismno. 2 (2022): 317-328.e6
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