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Our work on synthetic vaccines relates to the development of an influenza and anti-cancer vaccine. We have demonstrated the efficacy of a synthetic recombinant influenza vaccine, comprising a mixture of flagella expressing several conserved epitopes, in protecting both young and old mice against challenge viral infection. On the basis of these epitopes a vaccine that induces a broad-spectrum anti-influenza immune response in humans has been constructed and was shown to induce protective immunity in SCID mice reconstructed with human lymphocytes. These results were the basis for the establishment of a start-up company Biondvax. An epitope-based vaccine expressing peptides from the cancer-related Muc-1 repeating unit led to a significant decrease in tumor growth.
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Gal Aviel,Jacob Elkahal,Kfir Baruch Umansky, Hanna Bueno-Levy,Shoval Miyara,Daria Lendengolts,Lingling Zhang, Zachary Petrover,David Kain,Tali Shalit,Rina Aharoni,Ruth Arnon,
medRxiv (Cold Spring Harbor Laboratory) (2023)
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European Journal of Immunologyno. 10 (2022): 1539-1540
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R. Rachel Sarig, G. Aviel, K. B. Umansky, K. Elkahal, H. Levy-Bueno,S. Miyara, L. Lendengolts, D. Kain, T. Shalit,R. Aharoni,R. Arnon, R. Asleh,
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