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MILESTONE ACCOMPLISHMENTS
Delineation of the regulatory mechanism named Sequential Feedback Inhibition in Bacillus subtilis was one of the early findings indicating that alternative patterns of allosteric control existed in nature for the control of branched biochemical pathways. Comparative work in the Jensen Lab has since demonstrated a variety of allosteric control patterns in bacteria and in plants.
Formulation of the “Recruitment Hypothesis” (also called the “Patchwork Hypothesis”) in 1976 is frequently cited as a credible mechanism for differential specialization of homologous proteins and the expansion of metabolic repertoires.
Discovery and proof-of-structure of L-Arogenate (first named pretyrosine) was accomplished using a cyanobacterium, where it was demonstrated as a precursor of L-tyrosine. It was later shown to be a precursor of L-phenylalanine (or of both amino acids) in certain other organisms.
The nature of pathway diversity for phenylalanine and tyrosine biosynthesis at the enzymological level has been elucidated by a comprehensive program for characterization of enzymes and their regulation from a variety of plant and microbial organisms over a period of 40 years. These include broad-specificity enzymes utilizing both prephenate and L-arogenate (cyclohexadienyl dehydrogenase and cyclohexadienyl dehydratase), as well as narrow-specificity enzymes utilizing only L-arogenate or only prephenate.
研究兴趣
论文共 359 篇作者统计合作学者相似作者
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Lisa M Harlan-Williams, Marcia Pomeroy,W Todd Moore,Karin Chang,Devin C Koestler,Emily Nissen, John Fife,Megha Ramaswamy,Danny R Welch,Roy A Jensen
Journal of STEM outreachno. 2 (2024)
Stacey L. Hembruff, Alexander Dekonenko, John Thyfault, Mihaela Sardiu,Michael Washburn,Roy A. Jensen,Lisa M. Harlan-Williams
Cancer Researchno. 6_Supplement (2024): 1785-1785
Easwari Kumaraswamy,Raeann M. Koren Shimak,Sumedha Gunewardena,Karen L. Wendt, Dani Alexander, Stacey L. Hembruff,Roy A. Jensen
Cancer Researchno. 6_Supplement (2024): 2998-2998
Molecular Cancerno. 1 (2023): 1-4
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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David Standing,Prasad Dandawate, Jaimie Johnson, Sumedha Gunewardena, Michele T. Pritchard,Harsh Pathak,Dineo Khabele,Katherine Roby,Andrew Godwin,Roy Jensen,Scott Weir,Shrikant Anant
CANCER RESEARCHno. 7 (2023)
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