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My early amyloid related research in the UT Southwestern Alzheimer’s Disease Center is directed at determining amyloid precursor protein (APP) processing by neural cells in culture as a model system for the abnormal deposition of amyloid in the brain of Alzheimer’s disease patients. I have described a platelet APP bio-marker that correlates in a linear manner with the severity of patient dementia . In 2006, I published that human platelets utilize beta and gamma secretase to produce Aβ42 and that platelets from Alzheimer’s disease patients synthesize more Aβ42 than control platelets due to an increased activity of beta-secretase. Platelet A β42 levels may be an important bio-marker for Alzheimer’s disease and a means to monitor effectiveness of drug effect in clinical trials.
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Journal of the neurological sciences (2023): 120564-120564
Tamil Iniyan Gunasekaran,Dolly Reyes-Dumeyer,Kelley M Faber,Alison Goate,Brad Boeve,Carlos Cruchaga,Margaret Pericak-Vance, Jonathan L Haines,Roger Rosenberg,Debby Tsuang, Diones Rivera Mejia,Martin Medrano,
medRxiv : the preprint server for health sciences (2023)
Aging brain (2023): 100066-100066
medRxiv (Cold Spring Harbor Laboratory) (2023)
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Farid Rajabli,Penelope Benchek,Giuseppe Tosto, Nicholas Kushch,Jin Sha,Katrina Bazemore,Congcong Zhu,Wan-Ping Lee, Jacob Haut,Kara L Hamilton-Nelson, Nicholas R Wheeler,Yi Zhao,
medRxiv : the preprint server for health sciences (2023)
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Chaitanya Joshi, Karthigayini Sivaprakasam,Scott Christley,Sara Ireland,Jacqueline Rivas, Wei Zhang, Danielle Sader, Rebecca Logan,Doris Lambracht-Washington,Roger Rosenberg,Munro Cullum, Brian Hitt,
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