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个人简介
Using cancer genetics he has identified novel tumor suppressor genes (e.g. RNF8, MUS81 and PIRH2) and has also investigated the mechanisms of function and regulation of some major human tumor suppressor genes (e.g. BRCA1 and P53). Dr. Hakem is a world-class expert in cancer genetics, cell signaling and molecular oncology.
Several of his former trainees have obtained faculty positions or important positions in the private sectors.
The focus of our research is to characterize novel genetic risk factors, cell signaling and molecular oncology mechanisms that drive development and progression of human cancer. We also aim to identify novel strategies to improve cancer therapy.
Deregulation of cell signaling pathways not only impairs development and differentiation; it also frequently drives the development of human cancers. Therefore, our laboratory is investigating the role in cancer of different key siganling pathways including the DNA damage response, NOTCH, WNT, and the HIPPO pathways.
Cancer genetics and biochemistry are fundamental to our research. Mouse models, murine and human tumor lines that we have generated, and biopsies from cancer patients are being employed to conduct our studies. Using a multidisciplinary approach that involves scientists, clinicians, pathologists and bioinformatics experts we work towards our long-term goal of contributing to better diagnosis and therapy for cancer patients.
Several of his former trainees have obtained faculty positions or important positions in the private sectors.
The focus of our research is to characterize novel genetic risk factors, cell signaling and molecular oncology mechanisms that drive development and progression of human cancer. We also aim to identify novel strategies to improve cancer therapy.
Deregulation of cell signaling pathways not only impairs development and differentiation; it also frequently drives the development of human cancers. Therefore, our laboratory is investigating the role in cancer of different key siganling pathways including the DNA damage response, NOTCH, WNT, and the HIPPO pathways.
Cancer genetics and biochemistry are fundamental to our research. Mouse models, murine and human tumor lines that we have generated, and biopsies from cancer patients are being employed to conduct our studies. Using a multidisciplinary approach that involves scientists, clinicians, pathologists and bioinformatics experts we work towards our long-term goal of contributing to better diagnosis and therapy for cancer patients.
研究兴趣
论文共 35 篇作者统计合作学者相似作者
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V. Talya Yerlici,Audrey Astori,Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani,Janet N. Y. Chan,Razqallah Hakem,Brian Raught, Alexander F. Palazzo,Karim Mekhail
CELL REPORTSno. 3 (2024): 113891-113891
crossref(2023)
crossref(2023)
Nucleic acids researchno. 9 (2023): 4341-4362
crossref(2023)
Negin Khosraviani,V. Talya Yerlici,Jonathan St-Germain, Yi Yang Hou, Shi Bo Cao, Carla Ghali,Rehna Krishnan,Razqallah Hakem,Brian Raught,Karim Mekhail
biorxiv(2023)
crossref(2023)
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