基本信息
浏览量:1
职业迁徙
个人简介
Two major areas of investigation are in progress in our laboratory. In the first, polypeptide growth factors, hormonal-like agents responsible for the regulation of growth and/or maintenance of viability of eukaryotic cells, and their receptors are being examined with respect to structure and mechanism. The action of NGF, EGF, and basic fibroblast growth factor (bFGF) on responsive cultured cells (primarily PC12 and germane mutants) is being determined utilizing receptor chimeras. This work includes specific analyses of the mutations in FGFR3 that lead to a variety of skeletal dysplasias. The second block of studies addresses the manner in which protein turnover in eukaryotic cells is regulated. The co- and post-translational modification of the amino termini of nascent polypeptide chains is a key part of these processes and studies on the isolation, characterization, cloning, and expression of several germane enzymes are in progress. The connection between these modifications and the ubiquitin-based mechanisms of protein degradation also are under investigation.
研究兴趣
论文共 496 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Reference Module in Life Sciencespp.1-3, (2022)
Ralph A. Bradshaw, Roger L. Lundblad
Reference Module in Life Sciences (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn