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职业迁徙
个人简介
Creative Research Medal, University of Georgia, 2000
Grant Support -
“Functional Genomics of Maize Centromeres,” NSF
“Functional Genomics of Maize Chromatin,” NSF
Research Interests -
How do chromosomes move? Remarkably little is known about this basic motility event in higher plants. Our approach has been to combine immunocytochemistry, high-resolution 3D light microscopy, and forward genetics to understand the movement of chromosomes in maize. The organelle primarily responsible for chromosome movement is the kinetochore, which binds to centromeric DNA. Much of our current work is directed towards fulfilling the goals of a recently-renewed genome project on maize centromeres. We have ongoing projects on the roles of Centromeric Histone H3 and Centromere Protein C (CENH3, CENPC) in centromere/kinetochore structure. In addition we are focusing the epigenetic control of centromeres as well as chromatin-level gene silencing in maize heterochromatin. The spectacular cytology of the maize meiocyte, combined with deconvolution-based 3D light microscopy provides us with unparalleled resolution in our analyses.
Grant Support -
“Functional Genomics of Maize Centromeres,” NSF
“Functional Genomics of Maize Chromatin,” NSF
Research Interests -
How do chromosomes move? Remarkably little is known about this basic motility event in higher plants. Our approach has been to combine immunocytochemistry, high-resolution 3D light microscopy, and forward genetics to understand the movement of chromosomes in maize. The organelle primarily responsible for chromosome movement is the kinetochore, which binds to centromeric DNA. Much of our current work is directed towards fulfilling the goals of a recently-renewed genome project on maize centromeres. We have ongoing projects on the roles of Centromeric Histone H3 and Centromere Protein C (CENH3, CENPC) in centromere/kinetochore structure. In addition we are focusing the epigenetic control of centromeres as well as chromatin-level gene silencing in maize heterochromatin. The spectacular cytology of the maize meiocyte, combined with deconvolution-based 3D light microscopy provides us with unparalleled resolution in our analyses.
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Science (New York, N.Y.)no. 6689 (2024): 1292-1293
bioRxiv : the preprint server for biology (2024)
Esteban Bortiri, Rebecca Selby, Rachel Egger, Lindsey Tolhurst,Shujie Dong, Kayla Beam,Kerry Meier, Jon Fabish, Donna Delaney, Mary Dunn, Dawn Mcnamara, Kristin Setliff,
Nature Plantspp.1-5, (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The Plant Journalno. 4 (2023): 1003-1017
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