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个人简介
He started to work in this area more than 15 years ago and performed in 2000 the first human intramyocardial transplantation of autologous skeletal myoblasts in a patient with severe heart failure. He was then the PI of a randomised controlled trial of myoblast transplantation designed to assess the safety and efficacy of the technique. The suboptimal results of this study has then led the group to refocus on the use of cardiac progenitors derived from human embryonic stem cells (ESC). The laboratory is using small and large animal (including nonhuman primate) models of myocardial infarction and, in parallel with basic and preclinical studies on myocardial regeneration by ESC-derived cardiac progenitors, is involved in the optimisation of cell delivery and survival-enhancing techniques through the use of tissue engineering with the objective of an upcoming clinical translation in patients with end-stage heart failure who have exhausted conventional therapies.
研究兴趣
论文共 267 篇作者统计合作学者相似作者
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Aline Derisio de Lima, Hernán González‐King Garibotti, Myriam Assal, Assia Haddouche,Valérie Bellamy, Qing Dong Wang,Cecilia Granéli,Makoto Miyara,Jean‐Sébastien Silvestre,Karin Jennbacken,Philippe Menasché
Circulationno. Suppl_1 (2023)
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Frontiers in cardiovascular medicine (2023): 1206279
Journal of the American College of Cardiologyno. 9 (2023): 864-866
Journal of molecular and cellular cardiology (2023): 14-21
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Manon Desgres, Lorena Petrusca, Gwennhael Autret, Chloe Pezzana, Celine Marigny,Ashley Peuffier, Valerie Bellamy,Pierre Croisille,Albert Hagege,Bertrand Tavitian,Jean-Sebastien Silvestre,Philippe Menasche
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Chloé Pezzana,Audrey Cras,Fanny Simelière, Rose Guesdon,Manon Desgres,Bruna Lima Correa,Ashley Peuffier,Valérie Bellamy, Sara Gouarderes, Antonio Alberdi,Marie-Cécile Perier,Laetitia Pidial,
Biomaterials (2022)
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