基本信息
浏览量:1
职业迁徙
个人简介
Research interests
Our lab has three main projects:
1/ Understanding the structure and functions that control insulin secretion within islets
Our data the suggest that insulin secretion is targeted towards the vasculature. Ongoing projects in the lab are designed to prove this targeting. The work involves advanced imaging techniques, molecular biology and electron microscopy. We use islets from mice and humans to identify key proteins and then test for their role in controlling insulin secretion.
2/ Understanding the defects in sulin secretion that occur in disease
Changes in insulin secretion from beta cells are known to cause disease but despite a lot of work the basis of these changes is unclear. We have new data that shows that in a condition called prediabetes insulin secretion is dramatically upregulated. Using islets from diabetic mice and humans we are aiming to understand the principal mechanisms of control.
3/ Refining cell-based therapies to cure diabetes
We are working with Drs James Hudson and Enzo Porello to engineer induced pluripotent stem cells to make them secrete insulin. Our experiments are testing some of the factors we are finding to be important in the control of beta cells in the islet with an aim to enhance the control of insulin secretion. For diabetic patients, cell replacement therapies have the promise, one day, to provide a cure for disease.
Our lab has three main projects:
1/ Understanding the structure and functions that control insulin secretion within islets
Our data the suggest that insulin secretion is targeted towards the vasculature. Ongoing projects in the lab are designed to prove this targeting. The work involves advanced imaging techniques, molecular biology and electron microscopy. We use islets from mice and humans to identify key proteins and then test for their role in controlling insulin secretion.
2/ Understanding the defects in sulin secretion that occur in disease
Changes in insulin secretion from beta cells are known to cause disease but despite a lot of work the basis of these changes is unclear. We have new data that shows that in a condition called prediabetes insulin secretion is dramatically upregulated. Using islets from diabetic mice and humans we are aiming to understand the principal mechanisms of control.
3/ Refining cell-based therapies to cure diabetes
We are working with Drs James Hudson and Enzo Porello to engineer induced pluripotent stem cells to make them secrete insulin. Our experiments are testing some of the factors we are finding to be important in the control of beta cells in the islet with an aim to enhance the control of insulin secretion. For diabetic patients, cell replacement therapies have the promise, one day, to provide a cure for disease.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Belinda Yau, Sheyda Naghiloo,Alexis Diaz-Vegas, Austin V. Carr,Julian Van Gerwen, Elise J. Needham,Dillon Jevon, Sing-Young Chen,Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia,Gregory J. Cooney,
Journal of Biological Chemistryno. 3 (2023): 104343-104343
引用0浏览0引用
0
0
Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder,Matthew Sawyer,Thomas W. H. Kay,Stephen Farrell,Thomas Loudovaris,Lina Mariana,Davis McCarthy,Ruqian Lyu,Xin Liu,Peter Thorn,
Bioengineeringno. 12 (2022): 722-722
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn