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The O’Brien group’s research focuses on the development of new methods for organic synthesis. Projects in the group aim to develop novel, selective and synthetically useful methods that are technically simple, high yielding and robust. Historically, the group has studied asymmetric and mechanistic organolithium chemistry in detail. More recently, efforts have included extension to stereospecific Negishi and Suzuki-Miyaura sp3-sp2 cross-coupling reactions. In all projects, we apply the newly developed methodology to the synthesis of common motifs in blockbuster pharmaceuticals. We have ongoing interests in the design and synthesis of novel 3-D fragments for use in fragment-based drug chemistry, as well as developing new synthetic approaches for fragment elaboration. In collaboration with the Diamond X-Chem facility in Oxford, York 3-D fragments have been identified as useful starting points for drug discovery against two Covid-19 proteins. Another area of interest for the group is functionalised cyclic sulfoximines for use as medicinal chemistry building blocks.
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 2 (2024): e202314423-e202314423
Edward A. FitzGerald,Darius Vagrys,Giulia Opassi,Hanna F. Klein,David J. Hamilton,Vladimir O. Talibov,Mia Abramsson, Anna Moberg,Maria T. Lindgren, Claes Holmgren,Ben Davis,Peter O. ' Brien,
Nature Chemistryno. 3 (2023): 319-325
RSC MEDICINAL CHEMISTRYno. 12 (2022): 1614-1620
David J Hamilton, Marieke Beemsterboer, Caroline M Carter, Jasmina Elsayed, Rilana E M Huiberts,Hanna F Klein,Peter O'Brien,Iwan J P de Esch,Maikel Wijtmans
semanticscholar(2022)
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