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My research utilises microfluidic technologies to precisely define the cellular micro-environment and enable new insights into neurovascular biology.
In the brain, endothelial cells, perivascular cells, glia and neurons are intimately coupled, enabling tight regulation of the blood brain barrier, responses to metabolic demands, and inflammatory status. This has lead to the consideration of these cellular elements as part of a functional unit termed the 'neurovascular unit'. Disruption of this system is evident in many human neurological disorders. However, investigating this system in humans and modelling the complex interactions in vitro is particularly challenging.
In the brain, endothelial cells, perivascular cells, glia and neurons are intimately coupled, enabling tight regulation of the blood brain barrier, responses to metabolic demands, and inflammatory status. This has lead to the consideration of these cellular elements as part of a functional unit termed the 'neurovascular unit'. Disruption of this system is evident in many human neurological disorders. However, investigating this system in humans and modelling the complex interactions in vitro is particularly challenging.
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Francesca Sartor, Borja Ferrero-Bordera,Jeffrey Haspel, Markus Sperandio,Paul M Holloway,Martha Merrow
Circulation researchno. 6 (2024): 618-634
Free Radical Biology and Medicine (2023): S33-S33
Jakob Walther, Elena Marie Kirsch, Lina Hellwig,Sarah S. Schmerbeck,Paul M. Holloway,Alastair M. Buchan,Philipp Mergenthaler
Journal of Neuroscience Researchno. 5 (2021): 1276-1307
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