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个人简介
Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and mechanics of cytoskeletal polymers using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.
研究兴趣
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Kshitiz Parihar, Seung-Hyun Ko,Ryan Bradley, Phillip Taylor, N. Ramakrishnan,Tobias Baumgart,Wei Guo,Valerie M. Weaver,Paul A. Janmey,Ravi Radhakrishnan
Methods in Enzymology (2024)
Joonho Yoon,Zhenan Liu, Mathew Alaba,Leslie A. Bruggeman,Paul Janmey, Carlos Arana, Oluwatoyosi Ayenuyo, Isabela Medeiros,Sean Eddy, Matthias Kretzler,Joel M. Henderson, Abijit Naik,
biorxiv(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 16 (2023)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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biorxiv(2023)
CURRENT OPINION IN CELL BIOLOGY (2023): 102281-102281
Kiet A Tran,Brandon J DeOre, David Ikejiani,Kristen Means,Louis S Paone, Laura De Marchi,Łukasz Suprewicz, Katarina Koziol,Julien Bouyer,Fitzroy J Byfield,Ying Jin,Penelope Georges,
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