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Cell membranes are natural borders for signal transduction between cells and their environment. Different strategies to enable signals to cross the membrane barrier employ protein classes such as G protein-coupled receptors (GPCRs), ion channels, and transporters. Our research is directed at understanding transmembrane signalling by GPCRs. We investigate the inner workings of these proteins and their interaction with signalling proteins like G proteins and arrestins. Using different spectroscopic techniques (including EPR/DEER), X-ray crystallography and cryo-EM, we aim to get insight into the mechanism, specificity and structural basis of these interactions. The knowledge of how GPCRs work on a molecular level will help to understand their role in health and disease.
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The Journal of biological chemistryno. 2 (2024): 105649-105649
Paule Hermet,Benoît Delache,Cecile Herate, Esther Wolf,Gaily Kivi,Erkki Juronen,Karl Mumm,Eva Žusinaite,Denis Kainov, Eve Sankovski, Kai Virumäe,Anu Planken,
PLoS pathogensno. 8 (2023): e1011532-e1011532
Shuya Kate Huang,Louis-Philippe Picard, Rima S. M. Rahmatullah,Aditya Pandey,Ned Van Eps,Roger K. Sunahara,Oliver P. Ernst,Adnan Sljoka,R. Scott Prosser
Nature Structural & Molecular Biologyno. 4 (2023): 502-511
Robert Prosser, Shuya Huang, Rima Rahmatullah,Aditya Pandey,Ned Van Eps,Roger Sunahara,Oliver Ernst,Adnan Sljoka
crossref(2022)
Microscopy and Microanalysisno. S1 (2022): 356-358
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