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职业迁徙
个人简介
Research Summary
Research has involved both basic and clinical studies focused on the biochemical and biological actions of a gene family we first described in 2001 (the SIBLING or Small Integrin Binding LIgand N-linked Glycoprotein family). The research has shown that SIBLINGs are secreted intrinsically disordered proteins that bind multiple partners and modulate their partner’s normal biological activity. SIBLINGs are induced in different cancers where their actions facilitate tumor cell enhanced invasiveness and evasion of immune surveillance. The diagnostic utility of SIBLINGs has been studied through developing competitive and sandwich based ELISAs for their quantitative measurement.
Aging-specific research has involved developing biomarkers for sentinel homeostatic pathways such as inflammation (neopterin), senescence (chitotriosidase) and apoptosis (sFas, cytochrome C) to assess phenotypic consequences of altered extracellular signaling. The impact of aging and autoimmunity on signal transduction has been investigated by studying agonistic autoantibodies against the angiotensin II type 1 receptor. These autoantibodies activate their target receptor promoting chronic inflammation and are associated with at-risk status in older adults. Current studies are focused on whether the autoantibodies are predictive of time to diagnosis and time to death in cancer and other diseases associated with a high chronic inflammatory burden.
Technology Expertise Keywords
Biomarkers; Immunoassays; High Performance Liquid Chromatography; Tissue Culture; Pre-clinical Mouse Models
研究兴趣
论文共 170 篇作者统计合作学者相似作者
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Jeong-Seok Nam, Adam M. Suchar, Mi-Jin Kang,Christina H. Stuelten,Binwu Tang, Aleksandra M. Michalowska, Larry W. Fisher,Neal S. Fedarko,Alka Jain,Jan Pinkas,Scott Lonning,Lalage M. Wakefield
crossref(2023)
Jeong-Seok Nam, Adam M. Suchar, Mi-Jin Kang,Christina H. Stuelten,Binwu Tang, Aleksandra M. Michalowska, Larry W. Fisher,Neal S. Fedarko,Alka Jain,Jan Pinkas,Scott Lonning,Lalage M. Wakefield
crossref(2023)
Clinical immunology (Orlando, Fla.) (2023): 109324-109324
Pavan S Krishnan,Fernando T Zamuner, Carolyn M Jenks, Johnny Y Xie,Lisa Zhang, Mohammed Lehar,Neal S Fedarko,Mariana Brait,John P Carey
Journal of visualized experiments : JoVE (2023)
Arthur Jason Vaught,Theresa Boyer, Efthymios Ziogos, Nuria Amat-Codina,Anum Minhas,Kristin Darwin,Alexia Debrosse,Neal Fedarko,Irina Burd,Ahmet Baschat,Garima Sharma,Allison G Hays,
Placenta (2023): 1-6
Pavan S. Krishnan,Fernando T. Zamuner, Carolyn M. Jenks, Yanjun Xie,Lisa Zhang, Mohammed Lehar, Marcos Iglesias,Neal S. Fedarko,Mariana Brait, John P. Carey
crossref(2022)
Pavan S. Krishnan,Fernando T. Zamuner, Carolyn M. Jenks, Yanjun Xie,Lisa Zhang,Mohammed Lehar, Marcos Iglesias Lozano,Neal S. Fedarko,Lauren R. DeVine,Mariana Brait,Robert N. Cole, John P. Carey
crossref(2022)
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