基本信息
浏览量:42
职业迁徙
个人简介
We have successfully generated primordial germ cell-like cells (PGCLC) in vitro from mouse ESCs and iPSCs. As the name suggests, these cells behave like primordial germ cells, which are responsible for producing sperm and oocytes. We confirmed that these cells contribute to the generation of healthy offspring. We have used our PGCLC as a model to investigate a number of key mechanisms for germ cell development, including the transcription and signaling regulators and the epigenome reprogramming mechanism. We have also established methods for the proliferation of PGCLCs and their differentiation to spermatogonial stem cells in vitro. Using mouse PGCLCs as our model, we are investigating oocyte development, meiosis, and the effects of sex chromosome abnormalities on fertility.
研究兴趣
论文共 170 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Hiraku Tsujimoto,Azusa Hoshina,Shin-Ichi Mae,Toshikazu Araoka, Changting Wang, Yoshihiro Ijiri,May Nakajima-Koyama,Satoko Sakurai, Kazusa Okita,Ken Mizuta,Akira Niwa,Megumu K. Saito,
CELL REPORTSno. 2 (2024): 113602-113602
Takumi Okubo, Nicolas Rivron,Mio Kabata,Hideki Masaki,Keiko Kishimoto,Katsunori Semi,May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy,Hideyuki Sato,Hiromitsu Nakauchi,Knut Woltjen,
Natureno. 7998 (2024): 357-366
Takumi Okubo,Nicolas Rivron,Mio Kabata,Hideki Masaki,Keiko Kishimoto,Katsunori Semi,May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy,Hideyuki Sato,Hiromitsu Nakauchi,Knut Woltjen,
biorxiv(2024)
BMC Genomicsno. 1 (2024): 1-12
Serena F. Generoso,Maria Victoria Neguembor,Elliot A. Hershberg,Ruslan I. Sadreyev,Kazuki Kurimoto,Yukihiro Yabuta, Raffaele Ricci, Pauline Audergon,Moritz Bauer,Mitinori Saitou,Konrad Hochedlinger,Brian J. Beliveau,
biorxiv(2023)
Toshiaki Yachimura, Hanbo Wang,Yusuke Imoto, Momoko Yoshida,Sohei Tasaki,Yoji Kojima,Yukihiro Yabuta,Mitinori Saitou,Yasuaki Hiraoka
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Current opinion in genetics & development (2023): 102091-102091
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn