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The laboratory is focused on translational research projects in lung and pancreatic cancer, two of the most deadly cancers with overall five-year survival rates of 15% and 2-5%, respectively. Greater understanding of the molecular basis of their malignancy will provide insights for improving the early diagnosis and treatment against these diseases.
The primary goals of our lung cancer projects are to identify novel genes or proteins that are better than clinical predictors alone in predicting clinical outcome or response to therapies. We profile the gene expression and genomic aberrations of a large number of human lung cancer samples using microarray techniques, apply computational bioinformatic algorithms to identify the predictive genes or gene signatures, and validate them by realtime quantitative PCR technique. The biological functions of the predictive genes are then studied using in vitro lung cancer cell line model, primary lung cancer xenograft models and orthotopic rodent models of human lung cancers.
The primary goals of our lung cancer projects are to identify novel genes or proteins that are better than clinical predictors alone in predicting clinical outcome or response to therapies. We profile the gene expression and genomic aberrations of a large number of human lung cancer samples using microarray techniques, apply computational bioinformatic algorithms to identify the predictive genes or gene signatures, and validate them by realtime quantitative PCR technique. The biological functions of the predictive genes are then studied using in vitro lung cancer cell line model, primary lung cancer xenograft models and orthotopic rodent models of human lung cancers.
研究兴趣
论文共 307 篇作者统计合作学者相似作者
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Frank C. Detterbeck,Marcin Ostrowski, Hans Hoffmann,Ramón Rami-Porta, Ray U. Osarogiagbon, Jessica Donnington, Maurizio Infante,Mirella Marino,Edith M. Marom,Jun Nakajima,Andrew G. Nicholson,Paul van Schil,
Journal of Thoracic Oncology (2024)
Ramón Rami-Porta, Katherine K. Nishimura, Dorothy J. Giroux,Frank Detterbeck,Giuseppe Cardillo,John G. Edwards,Kwun M. Fong,Meredith Giuliani,James Huang,Kemp H. Kernstine,Edith M. Marom,Andrew G. Nicholson,
Journal of Thoracic Oncology (2024)
Ramón Rami-Porta, Katherine K Nishimura, Dorothy J Giroux,Frank Detterbeck,Giuseppe Cardillo,John G Edwards,Kwun M Fong,Meredith Giuliani,James Huang,Kemp H Kernstine,Edith M Marom,Andrew G Nicholson,
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)
Dalia Barsyte-Lovejoy, Suzanne K. Lau,Paul C. Boutros, Fereshteh Khosravi,Igor Jurisica, Irene L. Andrulis,Ming S. Tsao,Linda Z. Penn
crossref(2023)
Dalia Barsyte-Lovejoy, Suzanne K. Lau,Paul C. Boutros, Fereshteh Khosravi,Igor Jurisica, Irene L. Andrulis,Ming S. Tsao,Linda Z. Penn
crossref(2023)
JCO global oncologyno. Supplement_1 (2023): 59-59
Julia Nguyen,Anthony Mammoliti,Sisira Kadambat Nair,Emily So,Farnoosh Abbas-Aghababazadeh, Christoper Eeles,Ian Smith,Petr Smirnov,Housheng Hansen He,Ming-Sound Tsao,Benjamin Haibe-Kains
biorxiv(2023)
S. Nunes Martins Filho, M. Mikubo,Q. Li,E. L. Stewart,N. -A. Pham,M. Li,J. Weiss, J. Rosen,P. Pal, F. Sherpherd,B. Lok,N. Moghal,
Journal of Thoracic Oncologyno. 11 (2023): S110-S111
Dalia Barsyte-Lovejoy, Suzanne K. Lau,Paul C. Boutros, Fereshteh Khosravi,Igor Jurisica, Irene L. Andrulis,Ming S. Tsao,Linda Z. Penn
crossref(2023)
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