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My group works on differentiation and activation mechanisms of B lymphocytes of the mammalian immune system. Our work resulted in a better description of the B cell antigen receptor and we discovered several critical signal elements in B lymphocytes. Since 1998 we are applying synthetic biology approaches for a better study of signaling processes in lymphocytes. With this approach we made several key discoveries that resulted in a new hypothesis for B cell activation, namely the dissociation-activation model (DAM). In our signaling studies we are currently combining biochemical, genetic, molecular biology and synthetic biology techniques. We also have developed a modification of the proximity ligation assay (PLA) which allows us to study the molecular interactions around receptors of lymphocytes at the 10-20 nanometer range. With this technique we discover a new world of nanoscale molecular interaction in and at the membrane and open a venue to the field of Nanobiology.
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论文共 37 篇作者统计合作学者相似作者
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Jennifer J Schwarz, Lorenz Grundmann,Thomas Kokot,Kathrin Kläsener, Sandra Fotteler, David Medgyesi,Maja Köhn,Michael Reth,Bettina Warscheid
Kathrin Kläsener,Julia Jellusova,Geoffroy Andrieux,Ulrich Salzer, Chiara Böhler, Sebastian N. Steiner, Jonas B. Albinus,Marco Cavallari,Beatrix Süß,Melanie Boerries,Reinhard E. Voll,Bernd Wollscheid,
JOURNAL OF IMMUNOLOGYno. SUP1 (2019)
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