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职业迁徙
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Research description
I am interested in determining how human cytomegalovirus and other intracellular pathogens evade innate immunity. We recently developed ?Quantitative Temporal Viromics?, a proteomic technique that provides a systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection. Applied to human cytomegalovirus infection, this technology provided a slew of novel data, detailing how HCMV orchestrates the expression of >8,000 cellular proteins to manipulate intrinsic, innate, and adaptive immune defences in addition to host signalling and metabolism. As well as a variety of novel innate and adaptive immune ligands, we identified viral proteins present early in infection at the cell surface, potential therapeutic targets. In addition to ongoing investigations into HCMV, I am also interested in other viral and non-viral systems, including the identification of cell surface markers of senescence in collaboration with Dr. Matthew Hoare at Cambridge CRUK.
I am interested in determining how human cytomegalovirus and other intracellular pathogens evade innate immunity. We recently developed ?Quantitative Temporal Viromics?, a proteomic technique that provides a systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection. Applied to human cytomegalovirus infection, this technology provided a slew of novel data, detailing how HCMV orchestrates the expression of >8,000 cellular proteins to manipulate intrinsic, innate, and adaptive immune defences in addition to host signalling and metabolism. As well as a variety of novel innate and adaptive immune ligands, we identified viral proteins present early in infection at the cell surface, potential therapeutic targets. In addition to ongoing investigations into HCMV, I am also interested in other viral and non-viral systems, including the identification of cell surface markers of senescence in collaboration with Dr. Matthew Hoare at Cambridge CRUK.
研究兴趣
论文共 147 篇作者统计合作学者相似作者
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The Journal of general virologyno. 4 (2024)
Cell Host & Microbe (2024)
Lauren Kerr-Jones,Lior Soday, Nia Cwyfan-Hughes, Xinyue Wang,Leah Hunter,Robin Antrobus,Kelly Miners,Kristin Ladell,David A Price,Ceri A Fielding,Eddie CY Wang,Michael P Weekes,
crossref(2024)
biorxiv(2024)
Journal of virologyno. 3 (2023): e0184622-e0184622
Virginia-Maria Vlachava, Sepehr Seirafian,Ceri A Fielding, Simon Kollnberger,Rebecca J Aicheler,Joseph Hughes, Alexander Baker,Michael P Weekes, Simone Forbes,Gavin W G Wilkinson,Eddie C Y Wang,Richard J Stanton
Proceedings of the National Academy of Sciences of the United States of Americano. 49 (2023): e2309077120-e2309077120
Molecular cellno. 13 (2023): 2367-2386.e15
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