Matthew Redinbo
Distinguished Professor
Dept. of Chemistry
The University of North Carolina at Chapel Hill;Dept. of Genomics, The University of North Carolina at Chapel Hill;Center for Gastrointestinal Biology and Disease, School of Medicine, The University of North Carolina at Chapel Hill;Dept. of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill;College of Arts and Sciences, The University of North Carolina at Chapel Hill;Dept. of Microbiology and Immunology, The University of North Carolina at Chapel Hill
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Research Summary
Matthew Redinbo’s laboratory is focused on structure-function-inhibition studies in vitro and in utilizing suequent animal and ex vivo studies, largely toward the gut microbiota. He employs structural and chemical biology methods, along with biochemistry, cell-sed assays and in vivo model systems to understand how the gut microbiota impacts mammalian health. The work starts at the in vitro level, understanding at the mechanistic level how individual gut microbial enzymes process medically-relevant sutrates, including many drugs. Such approaches are also applied to human nuclear receptors, pulmonary defense proteins, and medically-relevant kinases. The lab then develops potent inhibitors to these enzymes, and tests validated compounds in mouse and rat model systems to examine a range of phenotypes as well as gut microbial next-generation sequencing and metabolomics.
研究兴趣
论文共 226 篇作者统计合作学者相似作者
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GUT MICROBESno. 1 (2024): 2295429-2295429
Bo Li,William Simke,Morgan Walker, Logan Calderone, Andrew Putz,Jon Patteson,Matthew Redinbo,Maria-Eirini Pandelia,Tyler Grove
Journal of Biological Chemistryno. 3 (2024)
Paulien Kristen,Janine Ziemons,Lars Hillege, Eva de Jong, Liselot Valkenburg, Judith de Vos,Maarten Deenen,Emma Hulshof, Irene van Hellemond, Hanneke Vestjens,Anne-Marie Dietvorst,Arnold Baars,
European Journal of Surgical Oncologyno. 2 (2024): 107661
Dave L Carlson, Mark Kowalewski,Khaldon Bodoor,Adam D Lietzan,Philip F Hughes,David Gooden,David R Loiselle,David Alcorta, Zoey Dingman, Elizabeth A Mueller,Irnov Irnov, Shannon Modla,
Cell chemical biologyno. 3 (2023): 465-476.e12
Joshua B. B. Simpson, Josh J. J. Sekela, Benjamin S. S. Carry,Violet Beaty,Shakshi Patel,Matthew. R. Redinbo
GUT MICROBESno. 1 (2023): 2203963
David Carlson, Mark Kowaleswski,Adam Lietzan,Philip Hughes, David Gooden,David Loiselle, David Alcorta, Zoey Dingman,Khaldon Bodoor, Elizabeth Mueller,Irnov Irnov, Shanon Modla,
crossref(2023)
Nature microbiologyno. 4 (2023): 611-628
Amanda L. Graboski, Mark E. Kowalewski,Joshua B. Simpson,Xufeng Cao, Mary Ha,Jianan Zhang,William G. Walton,Daniel P. Flaherty,Matthew R. Redinbo
CELL CHEMICAL BIOLOGYno. 11 (2023): 1402-+
Drug Metabolism and Dispositionno. 4 (2023): 427-435
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