基本信息
浏览量:34
职业迁徙
个人简介
The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like development and physiology?
Our focus recently has been on the rhomboid family of proteins. We initially discovered that rhomboids were novel intramembrane proteases, conserved across evolution, which regulate the production of extracellular signals. More recently we have become interested in non-catalytic rhomboid-like proteins, which we have found to function in the endoplasmic reticulum, where they control the fate of specific membrane proteins.
We study the genetics, cell biology and biochemistry of rhomboid-like regulation and function, using a variety of systems including Drosophila, mice and human cells. Although our main effort is aimed at understanding fundamental biology, we are also pursuing the potential medical significance of our basic discoveries, which includes cancer, inflammation, metabolic disorders and infectious diseases.
Our focus recently has been on the rhomboid family of proteins. We initially discovered that rhomboids were novel intramembrane proteases, conserved across evolution, which regulate the production of extracellular signals. More recently we have become interested in non-catalytic rhomboid-like proteins, which we have found to function in the endoplasmic reticulum, where they control the fate of specific membrane proteins.
We study the genetics, cell biology and biochemistry of rhomboid-like regulation and function, using a variety of systems including Drosophila, mice and human cells. Although our main effort is aimed at understanding fundamental biology, we are also pursuing the potential medical significance of our basic discoveries, which includes cancer, inflammation, metabolic disorders and infectious diseases.
研究兴趣
论文共 144 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
MOLECULAR CELLno. 2 (2024): 277-292.e9
Molecular Cell (2024)
PLoS biologyno. 8 (2023): e3002222-e3002222
The Journal of experimental biologyno. 3 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Joao Rocha, Satish Arcot Jayaram,Tim J. Stevens,Nadine Muschalik,Rajen D. Shah, Sahar Emran,Cristina Robles,Matthew Freeman,Sean Munro
biorxiv(2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn