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Our current understanding of T-cell mediated immunity has been established through the intense study of “conventional” αβ T-cells and the αβ T-cell receptor’s (TCR) remarkable ability to detect pathogen infected cells by recognising foreign peptide antigens presented by major histocompatibility complexes (MHCs). Despite human γδ T-cells being implicated in immunity to infectious diseases, the role of human γδ T-cells and the mechanisms they use to detect infection are largely unclear. γδ T-cells are defined as an innate-like T-cell population, operating outside of peptide/MHC recognition, comprising restricted γδTCR chain usage from birth and rapidly responding to TCR independent stimuli.
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论文共 38 篇作者统计合作学者相似作者
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Research Square (Research Square) (2022)
Anouk von Borstel,Priyanka Chevour, Daniel Arsovski, Jelte M. M. Krol,Lauren J. Howson,Andrea A. Berry,Cheryl L. Day,Paul Ogongo,Joel D. Ernst,Effie Y. H. Nomicos,Justin A. Boddey,Edward M. Giles,
Biochemical Society Transactionsno. 5 (2021): 1985-1995
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European journal of immunologyno. 12 (2021): 2708-3145
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