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个人简介
Research Interests
Since 1998, Dr. Gladwin’s research activities have led to numerous scientific discoveries. These discoveries have resulted in more than 210 published peer-reviewed manuscripts.
These investigations form the backbone of Dr. Gladwin’s current work in the Department of Medicine:
The discovery that the nitrite anion is a circulating storage pool for NO bioactivity (Gladwin, et al. PNAS 2000) that regulates hypoxic vasodilation (Cosby Nature Medicine 2003) and the cellular resilience to low oxygen and ischemia (Duranski JCI 2005).
The discovery of a novel physiological function for hemoglobin as an electronically and allosterically-regulated nitrite reductase (Cosby, et al. Nature Medicine 2003; Huang et al. JCI 2005).
The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction (Reiter, et al. Nature Medicine 2002; Morris et al. JAMA 2005; Minneci et al. JCI 2005; Rother et al. JAMA 2005).
The mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension (Gladwin, et al. NEJM 2004).
Keywords
Pulmonary Hypertension, Sickle Cell Disease, Nitrite Therapeutics
研究兴趣
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The Lancet Haematology (2024)
Research square (2024)
The Lancet Haematology (2024)
TRANSFUSION (2024)
Barry A. Borlaug,Katlyn E. Koepp,Yogesh N. V. Reddy,Masaru Obokata,Hidemi Sorimachi, Monique Freund, Doug Haberman, Kara Sweere, Kari L. Weber, Elysha A. Overholt, Bethany A. Safe,Kazunori Omote,
medRxiv : the preprint server for health sciences (2023)
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