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Tissue stem cells are present in every adult tissue and generally exist in a dormant state. When a tissue undergoes stress or is in a critical state, the inherent stem cells are activated by an as yet-to-be-defined signal to re-enter the cell cycle for self-renewal and differentiation into cells that aid in reconstruction of that tissue. In this manner, tissue stem cells participate in maintenance of homeostasis at the cell- or tissue-level. In our research, we seek to clarify how the signals aroused from neighboring cells or from other tissues regulate the maintenance, proliferation and differentiation of tissue stem cells, and how the tissue stem cell network is related to the maintenance of vital tissue functions. Our ultimate goal is to develop stem cell biology from a new perspective. By identifying multi-potential stem cells contained in the bone marrow stromal cell population that can be experimentally manipulated to differentiate into cells that have the potential to trans-differentiate and contribute to the repair of other tissue types, we believe we are making unique contributions to stem cell biology and regenerative medicine.
Tissue stem cells are present in every adult tissue and generally exist in a dormant state. When a tissue undergoes stress or is in a critical state, the inherent stem cells are activated by an as yet-to-be-defined signal to re-enter the cell cycle for self-renewal and differentiation into cells that aid in reconstruction of that tissue. In this manner, tissue stem cells participate in maintenance of homeostasis at the cell- or tissue-level. In our research, we seek to clarify how the signals aroused from neighboring cells or from other tissues regulate the maintenance, proliferation and differentiation of tissue stem cells, and how the tissue stem cell network is related to the maintenance of vital tissue functions. Our ultimate goal is to develop stem cell biology from a new perspective. By identifying multi-potential stem cells contained in the bone marrow stromal cell population that can be experimentally manipulated to differentiate into cells that have the potential to trans-differentiate and contribute to the repair of other tissue types, we believe we are making unique contributions to stem cell biology and regenerative medicine.
研究兴趣
论文共 203 篇作者统计合作学者相似作者
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Shinya Minatoguchi,Yasuyuki Fujita, Kuniyasu Niizuma,Teiji Tominaga,Toru Yamashita, Koji Abe,Mari Dezawa
STEM CELLS TRANSLATIONAL MEDICINE (2024)
Cellular and Molecular Life Sciencesno. 1 (2024): 1-21
BJU INTERNATIONALno. 3 (2024): 332-340
Toshihide Nagaoki,Gentaro Kumagai,Yoshiro Nitobe,Ayako Sasaki,Taku Fujita,Tatsuhiro Fukutoku, Kenya Saruta, Manami Tsukuda,Kanichiro Wada,Toru Asari,Yasuyuki Ishibashi,Mari Dezawa
Journal of neurotrauma (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cellular and Molecular Life Sciencesno. 11 (2022): 1-35
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