基本信息
浏览量:46
职业迁徙
个人简介
Research in our laboratory is focused on elucidating the function and evolutionary conservation of mechanisms that govern genome organization and gene expression in eukaryotes. We pay special attention to biogenesis, processing, and activity of non-protein-coding RNAs (ncRNAs) and their potential impact on chromatin.
Our general strategy is to take advantage of the power of fission yeast (S. pombe) genetics to address fundamental mechanistic questions. Importantly, S. pombe has a functional RNA interference pathway and its chromatin shares many post-translational modifications and protein components with mammalian systems. This makes fission yeast particularly well suited for studying the link between ncRNAs and epigenetic genome regulation. Building on the findings from yeast, we investigate similar mechanisms and potential conservation in more complex model systems such as mouse embryonic stem cells, transgenic mouse models, and Drosophila melanogaster.
Our main interests lie in:
RNA interference
Trans-generational epigenetic inheritance
Heterochromatin silencing
Helsmoortel-Van der Aa Syndrome
ChAHP complex
To investigate the aforementioned topics, we combine several complementary approaches, including forward and reverse genetics, next generation sequencing, bioinformatics, light and electron microscopy, protein crystallography and mass spectrometry. We have direct access to cutting edge technology platforms at the FMI, the Novartis Institutes of Biomedical Research, and the NCCR RNA&Disease.
Our general strategy is to take advantage of the power of fission yeast (S. pombe) genetics to address fundamental mechanistic questions. Importantly, S. pombe has a functional RNA interference pathway and its chromatin shares many post-translational modifications and protein components with mammalian systems. This makes fission yeast particularly well suited for studying the link between ncRNAs and epigenetic genome regulation. Building on the findings from yeast, we investigate similar mechanisms and potential conservation in more complex model systems such as mouse embryonic stem cells, transgenic mouse models, and Drosophila melanogaster.
Our main interests lie in:
RNA interference
Trans-generational epigenetic inheritance
Heterochromatin silencing
Helsmoortel-Van der Aa Syndrome
ChAHP complex
To investigate the aforementioned topics, we combine several complementary approaches, including forward and reverse genetics, next generation sequencing, bioinformatics, light and electron microscopy, protein crystallography and mass spectrometry. We have direct access to cutting edge technology platforms at the FMI, the Novartis Institutes of Biomedical Research, and the NCCR RNA&Disease.
研究兴趣
论文共 74 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Josip Ahel, Aparna Pandey,Michaela Schwaiger,Fabio Mohn, Anja Basters,Georg Kempf, Aude Andriollo,Lucas Kaaij,Daniel Hess,Marc Bühler
biorxiv(2024)
Cell reportsno. 6 (2023): 112569-112569
biorxiv(2023)
Marc Buehler, Shin Ohsawa,Michaela Schwaiger, Vytautas Iesmantavicius, Rio Hashimoto,Hiromitsu Moriyama,Hiroaki Matoba,Go Hirai,Mikiko Sodeoka,Atsushi Hashimoto,Akihisa Matsuyama,Minoru Yoshida,
biorxiv(2023)
引用0浏览0引用
0
0
Katarzyna J Duda,Reagan W Ching, Lisa Jerabek,Nicholas Shukeir,Galina Erikson,Bettina Engist,Megumi Onishi-Seebacher,Valentina Perrera,Florian Richter,Gerhard Mittler, Katharina Fritz,Mark Helm,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn